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Basic and Clinical Myology Laboratory

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24.01.2022 Tomorrow (Tuesday 2nd May) we have Associate Professor Jose Polo coming to speak to the Department of Physiology. A/Prof Polo is one of Australias leading researchers in the fields of stem cells and nuclear reprogramming and his talks are always worth attending. So if you want to see some really great research, come and join us. Everyone is welcome!

23.01.2022 The Basic & Clinical Myology Laboratory is pleased to report that we have had two successes in the latest NHMRC project grant round. JG Ryall (CI-A) & GS Lynch (CI-B) A simple method to improve stem cell transplant therapy. ($831,652 over 4 years). GS Lynch (CI-A) & GR Steinberg (CI-B, McMaster Univ) Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy ($780,476 over 4 years).... Overall, it is a wonderful result to have such a significant injection of funds into the group in one day and hopefully this is something that will encourage us to think strategically and plan for more success in the coming year. We still have a lot of work to do if we are to realise our expectations for the years ahead, but it is important to remember what it feels like on days like this so that we can harness that energy and enthusiasm during the times when everything just seems all too hard. If we stick together we can be a real force! Full details of all successful NH&MRC grants can be found at:

23.01.2022 For all of those aspiring young researchers out there, come down and meet with members of the Basic & Clinical Myology Laboratory this afternoon at the Medicine, Dentistry & Health Sciences at UniMelb Discover Research Expo from 2-4.30pm on the ground floor of the Alan Gilbert building. You can find out more about Honours in Physiology (including details on available projects) at the link below:

22.01.2022 Check out one of our recent papers, published in The American Journal of Pathology.

21.01.2022 An inspiring article on our labs PhD student Savant Thakur as featured in The University of Melbournes Report to Donors 2016. Savant Thakur is completing his PhD in the Faculty of Medicine, Dentistry & Health Sciences at UniMelb . Keep up the amazing work Savant!

21.01.2022 Congratulations Timothy Colgan on your recent PhD graduation! Timothy completed his PhD under the supervision of Paul Gregorevic at the Baker IDI Heart and Diabetes Institute and Gordon Lynch and Kate Murphy at The University of Melbourne . Well done Timothy!!

20.01.2022 The Basic and Clinical Myology Laboratory at The University of Melbourne proudly supports World Duchenne Awareness Day (WDAD), held annually on 7th September. The purpose of this day is to raise awareness and the profile of Duchenne Muscular Dystrophy, the most common and severe form of muscular dystrophy, which affects every 1:5000 male births. Duchenne causes progressive muscle wasting and weakness, eventually leading to loss of ambulation and premature death through res...piratory or cardiac failure. Our laboratory investigates the efficacy of novel pharmacological interventions to counteract the symptoms of Duchenne. We are committed to improving the lives of those living with this debilitating disorder through our research. Last year on WDAD (#WDAD15), we invited a group of boys and men with Duchenne and their families to tour our lab facilities and gave them an opportunity to have insightful interactions with researchers in our lab. The day was a great success and we were able to greatly increase the awareness about research into Duchenne. This year the theme of WDAD (#WDAD16) is early diagnosis. Several iconic buildings and landmarks across Australia will be lit up in red on the night of 7th September 2016 to shine their light on early diagnosis by increasing awareness of Duchenne. Increased awareness of the early signs of Duchenne will reduce the delay in diagnosis after symptoms are first observed, meaning that strengthening treatments will be available earlier and likely to be more effective. Click on the link below to see the full list of lighting partners http://mdqld.org.au/events-ca/world-duchenne-awareness-day/ #WDAD16 #EndDuchenne #EarlyDiagnosis #Shinealight #togetherwearestronger #cureDuchenne #researchmatters

19.01.2022 A great opportunity to present your research to a broad group (and win a pretty awesome prize!)

19.01.2022 Our very own Prof Gordon Lynch on a better way to keep those new year resolutions.

16.01.2022 Check out our recent review on the role of the amino acid glycine in skeletal muscle during times of stress, especially muscle wasting. The review describes the anti-inflammatory and cytoprotective properties and mechanism of action of the non-essential amino acid glycine. We highlight that glycine can modulate homeostasis in a variety of cell types via a receptor-mediated response and via intracellular metabolism. Recent studies from our lab have demonstrated that dietary supplementation with glycine can effectively protect muscles in a variety of wasting models including cancer cachexia, sepsis and calorie restriction. The research is supported generously by a project grant to Rene Koopman and Gordon Lynch from the NHMRC.

15.01.2022 Two of our own, Drs James Ryall and Kristy Swiderski are organising the Department of Physiologys seminar series in 2017. There are going to be some wonderful speakers, so come along and learn something new, everyone is welcome! First up, we have the newly appointed Dean of Medicine, Dentistry & Health Sciences at UniMelb, Prof Shitij Kapur who will be speaking about his research into schizophrenia.

14.01.2022 Gordon Lynch’s contribution to the recently published textbook on The Plasticity of Skeletal Muscle where he describes the therapeutic potential of slow muscle programming for muscular dystrophy and other muscle conditions. In his chapter he argues that mimicking exercise through electrical stimulation could have benefits for muscle health.

13.01.2022 The Basic and Clinical Myology Lab said farewell to Professor Allen Parcell on Friday. Allen has been with us on sabbatical for the last year and it has been wonderful having him as part of our team. Allen we hope you enjoyed your time with us and wish you every success when you return to BYU (Brigham Young University).

13.01.2022 Basic & Clinical Myology laboratory PhD student Savant Thakur featured in The Age today. The University of Melbourne Medicine, Dentistry & Health Sciences at UniMelb

13.01.2022 The Basic and Clinical Myology lab is very excited to welcome our new honours student of 2017 - Fran Alves! Fran completed a Bachelor of Biomedicine in 2016 at The University of Melbourne, majoring in Physiology. During her final semester, Fran completed the research based subject BIOM30003 in our lab, giving her the opportunity to work in a research environment and get a taste for what research is all about. This experience inspired Fran to undertake an honours year. We wish Fran all the best with the year ahead. It is great to have you in the team!

11.01.2022 This Tuesday (21st March) we have Prof Erica Fletcher speaking in our Departmental Seminar Series. Prof Fletcher is the head of the Visual Neuroscience Laboratory in the Department of Anatomy and Neuroscience. As always, everyone is welcome!

11.01.2022 Hai Ly recently presented his PhD research on metabolic reprogramming at the 2017 Gordon Research Conference on Myogenesis in Tuscany, Italy. We would like to thank Agilent Technologies for the generous Seahorse Bioscience Travel Award given to Hai to support his attendance at the conference. Keep up the great work Hai!

11.01.2022 The Basic and Clinical Myology Laboratory (soon to be the Centre for Muscle Research) is looking for (multiple) talented people to join our team as Research Assistants. If you have a background/interest in muscle, metabolism and/or cell culture experience we want to hear from you! More details can be found at the link below -

09.01.2022 The School of Biomedical Sciences at Medicine, Dentistry & Health Sciences at UniMelb will be hosting a half day symposia on August 30 dealing with Big Data. This symposia will address the many creative ways researchers are dealing with large datasets generated via genomics, transcriptomics, proteomics and metabolomics (and more). The symposia has been organised by our own Dr James Ryall and A/Prof Stuart Ralph from the Department of Biochemistry and Molecular Biology - University of Melbourne It is free to attend and should be a great day! Registration for the symposia can be found here https://goo.gl/Vaq9bP

09.01.2022 On Wednesday the 17th of May, Dr James Ryall from our laboratory will be presenting an Agilent Technologies sponsored webinar - A Metabolic Roadmap for Stem Cell Lineage Progression. Registration for the webinar is free and can be found at the link provided below. So, if you have an interest in stem cells and how metabolism plays an important role in the processes of lineage specification and reprogramming, sign-up! The webinar will also include a Q&A session at the end, where James will do his best to try and answer your questions.

09.01.2022 The Basic and Clinical Myology team of 2017!

08.01.2022 Congratulations to Prof. Gordon Lynch and A/Prof. Paul Gregorevic on their recent (2017) #NHMRC project grant success for Rescuing the dystrophin-glycoprotein complex to protect muscles from wasting conditions based on experiments led by Dr. Kristy Swiderski. Existing medical strategies to counteract muscle wasting are compromised and potentially futile because of a loss of critical signalling at the DGC, an important protein complex at the muscle membrane. This four-year p...roject will investigate new ways to restore DGC integrity and optimise the biochemical signalling needed to preserve and protect muscles during serious wasting conditions, including those associated with cancer and ageing. The grant is the first new collaborative project success for the two laboratories in the newly established Centre for Muscle Research in the Department of Physiology, School of Biomedical Sciences, in the Faculty of Medicine, Dentistry & Health Sciences at UniMelb at The University of Melbourne. Best of luck to everyone involved in the work, trying to better understand and treat severe muscle wasting disorders.

07.01.2022 The Stem Cell Metabolism and Regenerative Medicine group (within the Basic & Clinical Myology Laboratory) is looking for a talented Research Assistant to work on project related to skeletal muscle stem cell transplantation and muscle injury/repair. Please see here for details:

06.01.2022 Weve just put out the call for applications for our new EMCRA Collaborative Award! Our seed-funding scheme will help support new collaborations at the postdo...c level, between different departments in our school. We have a total of $60k that we will be giving out in funding. Please refer to the email that went out this morning for all of the associated forms and guidelines. Dont worry, its a short application form! If youre looking for a collaborator, remember we have our Networking Lunch this Wednesday. Best of luck to everyone who is contemplating putting in an application!! See more

06.01.2022 We are very excited to welcome our new Research Assistant, Megan Hepworth, to the Basic and Clinical Myology lab! In 2015, Meg completed a Bachelor of Science/Bachelor of Arts at the Australian National University in Canberra. In 2016 Meg completed her Honours year, graduating with first class honours from RMIT University, in Melbourne. Meg has joined the team to work on one of our recently awarded NHMRC project grants, focussing on methods to improve stem cell transplant therapy. A very warm welcome to the lab and to The University of Melbourne!

05.01.2022 It was a big week for researchers in the Basic and Clinical Myology Laboratory. Dr's Rene Koopman, Kate Murphy, Kristy Swiderski, and James Ryall all spoke at the annual conference of the Australian Physiological Society, while PhD student Savant Thakur was awarded a prize for his poster entitled "Heat shock protein 70 (Hsp70) overexpression drives myoblast fusion during C2C12 cell differentiation" Great to see Savant getting recognised for his outstanding efforts!

05.01.2022 Gordon Lynchs contribution to the recently published textbook on The Plasticity of Skeletal Muscle where he describes the therapeutic potential of slow muscle programming for muscular dystrophy and other muscle conditions. In his chapter he argues that mimicking exercise through electrical stimulation could have benefits for muscle health.

05.01.2022 Congratulations Hai Ly for being awarded the Royal Society of Victorias Young Scientist Research Prize in the field of Biomedical & Health Sciences! Hai is a PhD student in the Basic and Clinical Myology Laboratory and this award recognises excellence in biomedical research. Hais presentation was entitled Metabolism regulates asymmetric division and commitment to the myogenic lineage in skeletal muscle stem cells. Congratulations Hai on your wonderful achievement and keep up all the hard work! #Royal Society of Victoria

04.01.2022 Further to our previous post, the Basic & Clinical Myology Laboratory is pleased to announce more funding success, this time from the Cancer Council of Victoria. Dr. Kate Murphy (CI-A), Prof. John Silke (CI-B; WEHI), Prof. Gordon Lynch (CI-C), Prof. Lea Delbridge (CI-D). Using novel Fn14 inhibitory antibodies to treat cardiac cachexia in cancer ($263,000 over 3 years). Congratulations Kate Murphy!!

04.01.2022 Congratulations Dan Ham on the completion of your PhD! We are thrilled to announce that Dan has secured a postdoctoral position at Biozentrum at The University of Basel, in the laboratory of Markus Ruegg. We are very proud of you Dan and will miss you very much!

03.01.2022 We are looking for a talented young postdoc to join our Basic and Clinical Myology family! If you have recently been awarded a PhD in Physiology (or a related discipline) and have an interest in skeletal muscle wasting and weakness, then come and join us. The successful applicant will have the opportunity to work directly with Gordon Lynch and other senior members of the lab. You can find a link to the full advertisement below (with details of how to apply online), dont forget to include a full CV and to directly address the selection criteria.

03.01.2022 It was a big week for researchers in the Basic and Clinical Myology Laboratory. Drs Rene Koopman, Kate Murphy, Kristy Swiderski, and James Ryall all spoke at the annual conference of the Australian Physiological Society, while PhD student Savant Thakur was awarded a prize for his poster entitled "Heat shock protein 70 (Hsp70) overexpression drives myoblast fusion during C2C12 cell differentiation" Great to see Savant getting recognised for his outstanding efforts!

03.01.2022 Wonderful for the Centre for Muscle Research to be a part of the inaugural ‘Muscle Biology in Health and Disease’ conference at the National University of Singapore (March 1-2, 2018). Professor Gordon Lynch presented our NHMRC-supported research on mechanisms and treatments for muscle wasting disorders. A great line-up of international leaders in muscle biology; inspiring interactions with colleagues; and amazing hospitality (as always) from our hosts in Singapore. The conference was a great success and our warm congratulations to the organisers.

02.01.2022 We are very excited to welcome Grace Chou to the Basic and Clinical Myology lab! Grace is completing her Masters of Biomedical Sciences under the supervision of James Ryall and Gordon Lynch. Her project will focus on the role of glycolysis in muscle stem cell activation and skeletal muscle development. The results of Graces work will help us better understand how skeletal muscle is formed during the earliest stages of myogenesis. All the best with your studies Grace and a very warm welcome to the lab!

02.01.2022 Yet again we wish to congratulate Savant Thakur on another outstanding achievement! Savant Thakur is the recipient of The Lionel Murphy Endowment Postgraduate Scholarship! The award recognises Savants achievements and potential for success in his research on skeletal muscle biology with applications to improving muscle repair after injury and understanding and treating skeletal muscle diseases. Well done Savant and keep up the hard work.

01.01.2022 Wonderful for the Centre for Muscle Research to be a part of the inaugural Muscle Biology in Health and Disease conference at the National University of Singapore (March 1-2, 2018). Professor Gordon Lynch presented our NHMRC-supported research on mechanisms and treatments for muscle wasting disorders. A great line-up of international leaders in muscle biology; inspiring interactions with colleagues; and amazing hospitality (as always) from our hosts in Singapore. The conference was a great success and our warm congratulations to the organisers.