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Fiona Elsey Cancer Research Institute

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25.01.2022 FECRI researcher, Dr Aparna Jayachandran has recently published interesting new research into Liver cancer- Immune checkpoint molecules are regulated by transforming growth factor (TGF)-1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is a common primary liver malignancy accounting for approximately 80-90% of all liver cancers. HCC is frequently diagnosed in cirrhotic patients with higher risk in patients with under...lying liver disease resulting mainly from hepatitis B or C virus infection. Cancer immunotherapy based on immune checkpoint inhibitor drugs have transformed treatment in several cancers including HCC. This study provides valuable insights into the molecular mechanisms regulating immune checkpoint expression in HCC and identified biomarkers associated with poor prognosis in HCC patients. This paper was published in the International Journal of Medical Sciences and was conducted in close collaboration with liver cancer researchers at the Gallipoli Medical Research Foundation and the The University of Queensland Read more at www.fecri.org.au/liver-cancerpub21/ Dr Aparna Jayachandran MDP Photography & Video

25.01.2022 We are pleased to add some colour to 2020 as part of the Ballarat Arts Foundation's #creativecorona project. The initiative was designed to give all artists a chance to express, encouraged people to think outside the box and create a celebration of the year. Ballarat botanical artist, Paige Duggan has created a beautiful floral colouring in page, capturing the hope of our logos cornflower. We hope you enjoy this and we would love to see your work. Please tag a photo of your creation using #creativecoronaballarat, #ccballarat, Fiona Elsey Cancer Research Institute. Thank you to this projects supporters Helen Todd of Todd Design- Landscape Designs and the Ballarat Arts Foundation.

25.01.2022 Jim and Shirley Richards were ordinary citizens who have left an extraordinary legacy. The couple lived in Wendouree, and Jim worked for many years for Peter Amor Motors and Shirley worked at the home for the blind. The couple had no children and wished to use the funds they had accumulated over their lifetime to give back to their local community. Developments in cancer research and treatment were close to the couple’s heart. A charitable trust established in their name ...has donated $80,000 to the Institute to assist in funding a project for the Detection of Novel Proteins on Cancer Cells that evade the immune system. For more of this story head to fecri.org.au/supporter-story/jimshirleyleavelegacy/ Thank you to the trustee, BJT Legal for this grant.

25.01.2022 Thank you to the St Arnaud Country Club for having some fun and raising funds for our cancer research program!

25.01.2022 Join us tonight from the comfort of your lounge room for some trivia! Proceeds going to cancer research with thanks to Commerce Ballarat and Freight Bar and Restaurant It’s going to be a bit of midweek fun!

25.01.2022 Yesterday we were excited to celebrate the achievements of PhD candidate Tobias Meredith as his thesis was submitted for assessment. Titled: The influence of regulatory cell populations on surrounding cells. Tobias is researching the means by which regulatory T cells affect ant-cancer immune responses. He is studying experimental models of immune responses against cancer and then studying how regulatory cells can affect them.... On behalf of the team, congratulations Tobias! Federation University Australia

25.01.2022 Michael Unwin learnt the art of winemaking around the world with some of the most influential and forward-thinking winemakers of our time. When the time came to settle down to create his own wines, he built his winery in this region, because this is the geographical centre of our best viticultural areas in Western Victoria. Michael Unwin said. Michael Unwin Wines is located in Windermere Ballarat, Victoria, located around 9kms west from Ballarat CBD and nestled between t...he Pyrenees and Grampians, home of award-winning wines and the spectacular untamed ranges. After 16 years being located in Beaufort, Mike opened a new winery and vineyards in Ballarat January of 2020. The winery is well known for the consistently high-calibre wines across a broad range of styles and price. The wine buying fraternity love the no-nonsense approach and enjoy tasting and buying their wines from inside the actual winemaking cellar at Ballarat where they are kept busy. Michael Unwin Wines is a small family owned winery run by Michael and his wife Catherine. Employing a small local staff, the wines are processed and bottled on site from locally grown grapes sourced from their vineyards. Visitors are welcomed into their friendly cellar door, featuring towering racks of wine barrels and the aroma of maturing wines. Tastings are held around standing wine barrels and with a variety of wines on offer. Friendly knowledgeable staff will guide you through their extensive range of our single vineyard One Goat, Umbrella Man and Tattooed Lady varieties, as well as the extensive archive selection. You can also view any activities that may be happening in the winery at the time including vintage, barrel topping, bottling, labelling etc. Michael Unwin Wines feature a ‘fill your own’ cellar door only range, where you can bring along and fill your own bottle! One Goat of the One Goat label fame, will personally greet you as you come through the front gate. Michael Unwin Wines are available for bids in our Online Wine Auction. Go to www.fecri.org.au to visit the auction and support cancer research. Michael Unwin Wines #wineauction #cancerresearch #winelovers

24.01.2022 Join Team FECRI on Wednesday 29th July from the comfort of your lounge room for a bit of Online Trivia. Commerce Ballarat and Freight Bar and Restaurant have partnered to host this fun night and we'd love you to join our team. Proceeds from the night will be kindly donated to the Institute.

23.01.2022 We are based in Ballarat, non government funded, and are Australia’s only regionally based cancer research centre. The research is focused on the role of the immune system and how it relates and can be used to treat cancer. It is hoped that by identifying these proteins on the surface of cancer cells, druggable targets can be developed to allow the immune system to attack the cancer, without chemotherapy and radiation. The research aims to help patients with a broad range of ...cancers -- from Leukemia, Bowel, Ovarian, Breast, Renal, Lung, Melanoma and Pancreato-Biliary cancers, as well as haematological cancers. For more information on our research, please head to our website See more

23.01.2022 Ruby Pilven Ceramics Star of Hope for cancer research is available for order for Christmas. Stars are $20. Proceeds to cancer research. Order today at www.fecri.org.au/get-involved/christmas-star-of-hope/

22.01.2022 This is Jim Waight and he has a very personal reason for taking on a challenge for cancer research. In November 2019, Jim was diagnosed with Non-Hodgkin’s Follicular Lymphoma (a form of blood cancer). Since that time, this father of three has undergone six cycles of chemotherapy and in June 2020, he was declared to be in remission. ... Jim has pulled together a team of 11 very 'average' riders, to cycle 520km in two days from Swan Hill to Port Fairy, with the aim to raise over $20,000 for cancer research. We hope you can assist him in reaching this goal. For more information about Jim and how you can support this group of "Allsorts" and their challenge, visit fecri.org.au/fundraiser/jims-allsorts/

22.01.2022 Our work experience program welcomes 10 students each year to gain a firsthand experience of a working research lab. Although now we have paused this program because of restrictions, we miss these enthusiastic and bright young people and look forward to inspiring them into a future of science again in 2021. If you would like to apply for our work experience program in 2021 please email [email protected]... #NationalScienceWeek See more

22.01.2022 UnGala - You're Not Invited To Attend is TOMORROW! To get your party at home really happening our friends Sweat Dreams DJs are going to stream some groovy tunes straight to your loungeroom. You can join the fun by donating at www.fecri.org.au ... An email will be sent with a link to the exclusive gig and a video from Institute Director, Prof. George Kannourakis on Friday afternoon. Pick up your favourite takeaway, watch the video then get your dancing shoes on to enjoy the night in your home, not attending our important fundraiser for cancer research. Sweat Dreams DJs are real-life couple Jules and Daz from Ballarat, Victoria. They draw inspiration from a variety of sources including Disco, Baleric, Italo, Afrobeat, Boogie, House and anything with a groove you can dance to. They're all about the eyes closed, hands in the air, the light-hearted carefree vibe - connecting with people through music is their passion and if they are not mixing, they are in the crowd dancing. During the COVID19 pandemic, Sweat Dreams created ‘Voyeurismo Disco’ - a super funky series of live bi-weekly events on Twitch, streaming directly from their lounge in their home where they continue to share love and good times virtually. Thanks to our sponsors McCain Foods Australia

22.01.2022 Sue Bell created Bellwether Wines, based at the 1868 Glen Roy Shearing Shed in Coonawarra. She focuses on special parcels of fruit with no ferment larger than 1T primarily for herself and some contract work for local growers wanting to start their own brands. Sue believes wine alone is irresponsible and a bit strange, so has established a place to share life with wine in it. People are literally invited to see and get involved in the process. Bellwether Wines has much to ...offer. Not only do they produce a seriously tasty drop, you can stay on the property in a glamping bell top tent or bring your own tent using their campground facilities. Now what an experience that would be! No worries about drink-driving as you walk through the majestic red gums to your snuggly woollen doona covered bed and hot water bottle comfort. When fire restrictions allow, enjoy each evening with warmth, wine, food, stars, friendship and conversation by a beautiful camp fire. If you cannot physically get to Bellwether due to current interstate regulations at least you will be able to learn more about their wine straight from the creator. The Bellwether team have created three video tasting experiences (Whites, Reds & Premiums)....as if you were really onsite enjoying the ambience of beautiful Bellwether with Sue Bell. https://www.bellwetherwines.com.au//cellar-door-wine-tasti Sue has a degree in Oenology from Adelaide Uni, postgraduate studies in Viticulture. She has worked for some of the smallest and biggest wine companies in the world, with experience in most South Australian regions, Victoria, New South Wales, Tasmania and vintages in California and Bordeaux. Sue has served on numerous industry boards at a regional, state and national level, was dux of the prestigious Len Evans Tutorial and regularly judges at wine shows, including chair of several regional and National shows. Her wines have won numerous medals and trophies and she was Australian Society of Viticulture & Oenology Winemaker of the year in 2014. Sue is also graduate of the Australian Rural Leadership Program, has a 10 year old daughter and once won the blue ribbon for veggies at the Penola Show. She can often be found at Bellwether in her beloved Coonawarra, making wine, sour dough, gardening, cooking lamb or planning the next music gig or event. In addition to her virtual wine tastings, Sue has let us in on numerous chats over the last few months with some special guests, including our friends at Redman Wines. https://www.bellwetherwines.com.au/pages/videos-1 To bid on some of Bellwether's wines which have been generously donated to our Online Wine Auction, go to www.fecri.com.au Bellwether Wine Cellars #wineauction #cancerresearch #winelovers

22.01.2022 This is Federation University Australia PhD canidate Revati Sharma, analysing the presence of specific protiens after extracting from live cancer cells. Revati is conducting her PhD at the Institute into Renal cell carcinoma. #researchcontinueson

22.01.2022 You are invited to a special fundraiser for cancer research. Simply donate, order some takeway from your favourite local restaurant & make a night of it at home! Head to fecri.org.au/fundrai/ungalathanksfornotattendingfundraiser/ to be part of the night. Thank you to our sponsors for the evening McCain Foods Australia

21.01.2022 During the lockdowns of 2020, Joanie Rix from Bullarook has been very busy. Supported by dear friends, Joanie has turned a love for sewing, into making 400 + masks. $5 from the sale of each mask, going to cancer research. In October, as part of Breast cancer awareness month, Joanie came into the Institute and presented Professor Kannourakis with a cheque for $2100.00!... Joanie has been touched by cancer and is a long term, passionate advocate and fundraiser for the Institute. She has previously run coin collections across Ballarat in celebration of her cancer milestones- 5 years is worth more than 5 cents and 10 years years is worth more than 10 cents. If you would like to buy one of Joanie's fabric masks please email [email protected] or alternatively call the Institute on (03)53313101.

21.01.2022 When one person is diagnosed with cancer, it touches so many. We’ve lived a promise to help find a cure for cancer, and today we’re asking for your support to help us continue our work into cancer research. Donate today by visiting fecri.org.au... Thank you to the Elsey Family & Friends, MRL Media and our media partner SCA Ballarat for supporting our new campaign.

21.01.2022 Well done and thank you !!

21.01.2022 Today is Fiona's birthday. She would be so proud of how much we've achieved. What started with determination and a young inquiring mind all those years ago has come so far. ... Thank you for your continued support keeping Fiona's dream of cancer research in regional Victoria a reality.

21.01.2022 Mitchell Harris Wines is well known and loved by many, especially Ballarat locals for the Mitchell Harris Wine Bar. Based in Ballarat and surrounded by the great wine regions of Western and central Victoria, winemaker John Harris, works with growers in the Pyrenees, Macedon, Ballarat and Henty wine regions to craft wines that display distinctive varietal expression and reflect individual vineyard, vintage and regional character. Intrigued by its tastes, and the art and scie...nce behind its creation, John, whilst completing an Immunology degree, fell in love with everything about wine. After his first vintages at Brown Brothers in the mid 1990’s he never looked back and soon completed a wine science degree whilst gaining valuable cellar and winemaking experience in Western Victoria and also in Oregon. 8 years at Domaine Chandon, working with winemaking teams all over the world, the desire to create his own brand was ignited, and after moving back home to Ballarat and joining forces with his wine loving in-laws, the Mitchells, the Mitchell Harris wine story was born. From the classic Western Victorian pepper and spice in their Pyrenees reds to the cool climate focus and finesse of the Sabre sparkling, the hope is wines will give you a real glimpse into what makes central and western Victorian wine growing regions so special. In 2011 the team fell in love with an abandoned 150 year old workshop in central Ballarat, gave it a good clean and a lot of love, and created the Mitchell Harris Cellar Door and Wine Bar. It’s the place they call home and share their love of winemaking and all good things to eat and drink with locals and visitors alike. Take a look at www.fecri.org.au and support our Online Wine Auction. You will find some beauties generously donated by Mitchell Harris Wines. Mitchell Harris Wines #wineauction #cancerresearch #winelovers

21.01.2022 The Bendigo Bank Tissue Bank has recently received an important upgrade to ensure the ongoing momentum of our research interests. $200,000 of funding was been received from the Community Bank branches with assisting grants from the Percy Baxter Charitable Trust, James Kirkpatrick Charitable Trust and Patricia Madigan Charitable Trust for new equipment and relocation works. The Bendigo Bank Tissue Bank is a collection of human tissues that are stored as live cells in liquid ni...trogen at -200C and used for research later. It is a fundamental component to our research. Our tissue bank has continued to be managed at this time and gratefully accepting and processing tissue and blood samples. The Tissue Bank houses nearly 4500 patient samples- many from cancer patients as well as healthy samples that are vital to researchers work. This resource has seen incredible 52% growth on the last year.

20.01.2022 This is third year PhD canidate Ali Raza, working away in the lab. Ali is studying the novel functions of MAGMAS signaling in ovarian cancer progression and chemoresistance of these cancer cells. Ovarian cancer is the fourth most common cause of cancer-related death in Australian women, and research like Ali's, is key to improving outcomes for patients. For more information on our Ovarian cancer research group's work, please head to fecri.org.au/research-article/ovarian-cancer/

20.01.2022 Following from our team’s previous publication on the role of specialised immune MAIT cells and their relationship to Bowel cancer development, FECRI researcher, Professor Stuart Berzins has recently published new research. Thymic development of unconventional T cells: how NKT cells, MAIT cells and T cells emerge nature.com/articles/s41577-020-0345-y The paper explores findings on how these cells develop and their biology, adding to the understanding of their role in ca...ncer development. This paper was published in international journal nature.reviews Immunology in collaboration with groups from The University of Melbourne and the Murdoch Children's Research Institute

19.01.2022 Thank you for not attending the first ever UnGala for the Fiona Elsey Cancer Research Institute. We hope you are enjoyed a night at home; > Not dressing up > Not searching for a park... > Not making small talk > No posing for photos > No live auction Please know that you are supporting cancer research and making a difference. So sit back and watch this message from Institute Honorary Director, Professor George Kannourakis. We hope you can join us in person and on the dance floor next year. Save the date for the 2021 Cancer Research Ball Saturday 4 September.

19.01.2022 Join us for a beautiful evening at the Pink Ladies Dinner 2020 for breast cancer awareness month, Thursday 29 October at the Boatshed Restaurant Tickets $95 and include a 2 course dinner and Miami Gin cocktail on arrival. (Pink of course!) There will be a raffle with stunning prizes from Blue Pyrenees Estate, Gems and Jewels & more!... All funds raised go to our breast cancer research program. Book now to avoid disappointment at fecri.org.au/fundraiser/pink-ladies-dinner/. Tickets limited.

19.01.2022 Jimmys Licorice Allsorts are out on the road training for the Murray2Moyne event in March. The group are well on their way to raising $30,000 for Fiona Elsey Cancer Research Institute. Head over to the team's Facebook page to watch the journey.

19.01.2022 Pleased to share in #nationalscienceweek!- Congratualtions to Professor Nuzhat Ahmed on recent publication of a research case study investigating the positive outcomes of liquid nanoparticle drug loaded to chemotherpy to reduce its toxicity and therefore side affects for patients. This research has been completed in collaboration with groups from The University of Melbourne and RMIT University The publiucation - "In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel...-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer Xenograft Model." has been published in Applied Bio Material Journal - ACS Publications To read the article visit bit.ly/NuzatJune20

18.01.2022 Cancer cells are highly intelligent and have many tactics in avoiding being killed by chemotherapeutics. In response to the physical stress experienced by the cancer cell with chemotherapy exposure, the cell switches on and ramps up the activity of a pro-tumour molecule (red dots). Dr Elif Kadife, PhD, Post-doctoral Research Fellow explains "In our work, we are observing a close interaction between this molecule (red dots) and the ‘powerhouse’ or mitochondria (green) of can...cer cells. We are investigating if the red molecule is helping to reduce the stress in cancer cells by altering the activity of mitochondria. Blocking this molecule may lead to more effective treatment options for ovarian cancer patients." Donations can be made at www.fecri.org.au and go directly to cancer research. Thank you for your support.

18.01.2022 With many of our fundraising programs put on hold because of the Covid-19 pandemic, we need your help to keep going. We are a regional organisation making a world-class contribution to cancer research, that requires the continued support of the community. Please support our important work and make a tax deductable donation today at fecri.org.au.... Alternatively our Gift team on (03) 53313101

18.01.2022 "Our local partnership recognises that together we are stronger than the sum of our parts. We have a common belief that a united Ballarat is a stronger Ballarat." Full article here: https://www.thecourier.com.au/.../we-are-stronger-when.../ Today on #GivingTuesday, we have come together with the @ballaratfoundation, Ballarat Health Services 3BA 102.3 FM Ballarat International Foto Biennale to promote local giving. To support the campagn, visit https://buff.ly/39pGBUt

18.01.2022 Put your lockdown fitness to the test this January and in doing so help fight cancer. Lighthouse Classic 'Shine A Light on Cancer' - 1- 31Jan 2021 will take place for the first time this year throughout Australia in 2021. Simply walk or run along the beautiful 12km route Great Ocean Road from Urquhart Bluff, to Aireys Inlet Lighthouse or choose your own local destination, maybe even a lighthouse, anytime during the month of January.... For more information and on how to register visit fecri.org.au/fundraiser/lighthouse-classic/ Proudly sponsored by A La Grecque, Eagles Nest Fine Art Gallery, Aireys Inlet, Register Now, Ocean Inlet, Yeux Apparel.

17.01.2022 ‘Bindi’, 50 kilometres north-west of Melbourne in the Macedon Ranges, is the family property of the Dhillon family. Originally purchased in the 1950s as part of the larger grazing farm ‘Bundaleer’, ‘Bindi’ is a 170 hectare farm of which 7 hectares are planted to Chardonnay and Pinot Noir. Fifteen hectares are dedicated to managed plantation eucalypts for high grade furniture timber whilst the remainder of the land is maintained as remnant bush land and important indigenous g...rasslands. The Bindi vineyard is the fundamental focus. The vineyard and winemaking philosophy is to seek balance and purity in the expression of various individual vineyard sites and this philosophy is applied to farming and conservation at ‘Bindi’; the preservation of the natural harmony. Michael was born in the town of Gisborne (where his family on his mother Kaye’s side have been since 1853) , 55kms north west of Melbourne, and grew up at Bindi on the farm just outside the township. Today he and his family produce chardonnay and pinot from their vineyard at Bindi which Bill and Michael Dhillon established in 1988. Michael served as assistant winemaker to Stuart Anderson from 1991 until 1998 when he assumed full responsibility. Michael learned his craft working with Stuart as well as experiencing vintages in Europe, where he spent time with the Champagne house of Jean Vesselle in Bouzy, with Alain Graillot in Croze-Hermitage and four vintages in Tuscany at Tenuta di Valgiano. During the mid 1990s Michael also worked with John Wade over parts of three vintages when John was establishing Howard Park Winery. Michael’s passion for Burgundy has seen him visit over 100 different domaines over two decades. To bid on wine generously donated to our Online Wine Auction by Bindi Wines, please visit www.fecri.org.au Bindi Wine Growers #wineauction #cancerresearch #winelovers

17.01.2022 Janet is a champion campaigner for our research. Please get behind the Lighthouse Classic 'Shine A Light on Cancer' - Jan 2021 and take a walk to a Lighthouse anytime this January. Register now at www.fecri.org.au

17.01.2022 Thank you to all involved in the Answer for Cancer dinner-The wonderful event sponsors Blood Suzuki, Eagles Nest Fine Art Gallery, Aireys Inlet, Ocean Inlet, Ray White Highton, Great Ocean Road Gin and McHarry's Busline, all auction donors and lastly to eveyone that donated their tickets sales. Although it was heartbreaking to not be able to hold the event, it raised $24,354 for cancer research. Thank you to the Hair Today Bare Tomorrow fundraising committee for all your hard work. An online auction will be held shortly. STAY TUNED

17.01.2022 Jenny Morrison, wife of Prime Minister Scott Morrison, has a message for all women in Australia this #WomensHealthWeek don’t put off your routine health checks.

17.01.2022 Another great step forward from our Ovarian cancer group. John Turner Professorial Cancer Research Fellow, Professor Nuzhat Ahmed, Dr Elif Kadife, The University of Melbourne PhD candidate Ruth M Escalona and Professor George Kannourakis have identified a new potential strategy to overcome chemoresistance-associated in ovarian cancer patients who do not have many treatment options. This recent research paper TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells has been published in international science journal- Biomedcentr. Read more...fecri.org.au/ovariancanceroct20/

16.01.2022 REGISTRATIONS ARE NOW OPEN. Bring on 2021! www.ballaratcycleclassic.com.au ON THE ROAD, IN THE BUSH & ONLINE. 100% to cancer research at the Fiona Elsey Cancer Research Institute. For event details & to register head to the website.... See you Sunday 21 February 2021. Thank you to our sponsors BJT Legal Eclipse Ford Ballarat - LMCT 9011 , Optus, PETstock, @protect, SCA Ballarat Dennis Family Homes Homes, Lake Imaging Eureka Concrete and Cyclescape

15.01.2022 Are you heading to the coast these holidays? Please get behind the Lighthouse Classic 'Shine A Light on Cancer' - 1- 31Jan 2021 and take a walk to a Lighthouse anytime this January. For more information and how to register, head to at www.fecri.org.au.

15.01.2022 It’s really important during this difficult time, you keep seeing your GP for both your cancer and non-cancer needs. Early detection of cancer and it’s recurrence is crucial. - Dr Ines Rio General Practitioner We want to encourage you to keep seeing your GP if you have health concerns- prevention and early detection are some of our best defences against cancer. Speak to your GP via telehealth or in person.... #staysafe #lookafteryourself #speaktoyourGP See more

15.01.2022 Visit fecri.org.au for more information

14.01.2022 Our team captures some amazing images in their work. This image shows nests of bowel cancer coloured in cyan with various immune cells coloured in red and green. The cells our team are interested in this case, are the immune cells which stain both red and green together.... One of these cells can be seen just to the left of the very top nest of the tumour cells. Fiona Elsey Cancer Research Institute

14.01.2022 Sharing some bright news. Researchers at the Fiona Elsey Cancer Research Institute have published results examining the aggressive subtype triple-negative breast cancer. Our new Breast cancer research group commenced work at the Institute in March following a private philanthropic seed funding donation and the outstanding community’s support of February’s Ballarat Cycle Classic that raised a record $300,000.

14.01.2022 You and your immune system need MAITS. As #nationalscienceweek comes to an end, Institute PhD canidate Tamekha Develyn is hosting content for Federation University Australia Pocket Science, where she talks about her project, introdces you to some her lab friends and takes you on a tour of her research lab. If you have some home learning future scientists, click on the link below to register for Federation University Australia Pocket Science content.

14.01.2022 Following our successful Online Wine Auction, a few of our wineries have some specials for you. Happy Shopping! Michael Unwin Wines... Jacks Cellarbrations Ballarat and Friendly Grocer Mount Langi Ghiran Captains Creek Organic Wines Taltarni Vineyards See more

12.01.2022 This is a great clip that shows one of our experiments in action. The green cells are a leukaemia cell. The small cells are natural killer cells, which are lymphocytes that kill the leukaemia cell lacking MHC protein. When a cell dies, it turns red. Watch as the quantity of red cells grow. #biology #scienceinaction

12.01.2022 We are so excited to collaborate with The Ballarat Foundation, the Ballarat Health Services Foundation & 3BA 102.3 FM Christmas Appeal as part of #GivingTuesday - Tuesday 1 December. This global generosity movement is so aligned with our history and vision, aiming to unleash the power of people + organisations to transform their communities + the . For more information or to donate, please visit https://bit.ly/giveballarat

12.01.2022 Jimmy's Allsorts are preparing for the start of their Murray to Moyne 2021 adventure today as they leave Ballarat for Swan Hill, their starting destination. They head off tomorrow. The crew have gathered a fabulous collection of raffle prizes of mini escapes. We'd be grateful if you would consider purchasing some tickets and supporting Jimmys Licorice Allsorts.

12.01.2022 In the news- Thank you The Courier for sharing some much needed good news.

12.01.2022 A Priceless Inheritance. Established in 1860 Tahbilk is one of Australia's most beautiful and historic family owned wineries. Located in the Nagambie Lakes region of central Victoria (120kms north of Melbourne), one of the nation's premium viticultural areas. The property comprises some 1,214 hectares of rich river flats with a frontage of 11 kms to the Goulburn River and 8 kms of permanent backwaters and creeks. Purchased by the Purbrick family in 1925, Tahbilk is home to 5...Continue reading

12.01.2022 Thank you to The Courier for sharing a spot of good news for our cancer research program. For more information on our research and how you can support head to fecri.org.au

11.01.2022 This morning Rotary Bowelscan announced support for our Bowel cancer research program of $20,000 per year for 3 years. Australia has one of the highest rates of Bowel cancer in the world. Regular screening and early detection are key with a 98% successful rate, when detected early. The Bowelscan program aims to detect early.... The funding will support Bowel cancer research to be developed further following our groups discovery of subset of immune cells in the bowel can misbehave and release chemical messengers that promote bowel cancer and inhibit other immune cells. Rotary Bowelscan testing kits are affordable, easy to use and include testing by approved pathologists as well as notification of results. These kits are available in May across regional Victorian pharmacies and online for $20. For more information on the Bowelscan or to purchase a kit online visit rotarybowelscan.com.au/ Professor George Kannourakis, Rotary's Barry Stokes with Jason Kelly PhD canidate Bowel cancer.

11.01.2022 Our new Breast cancer research group has published their first results detailing the role of pregnancy associated plasma protein in aggressive subtype triple-negative #breastcancer. Triple-negative breast cancers account for 10%20% of breast cancers and have been reported to be more aggressive, associated with poorer survival than other subtypes of breast cancers. Notably, the triple-negative subtype of breast cancer is encountered more often in pregnancy and has an aggress...ive clinical course. This is the first work in the field describing the behaviour and function of a pregnancy associated plasma protein that is highly found in aggressive triple-negative breast cancers. High PAPPA concentrations are generally detected in blood of pregnant women. The research sought to understand its functional consequences, and findings revealed that it plays an important role in regulating key cell motility networks in breast cancers. This research has provided evidence that could lead to a potential therapeutic target for the subset of breast cancers with elevated levels of the plasma protein that will improve treatment outcomes for these patients. go.nature.com/3h6hV4g Scientific Reports

10.01.2022 Thanks to the Community Rewards program of Ryans IGA Ballarat - Mt Clear, Northway & Pleasant Park for a recent donation of $4400 to our cancer research program. The Institute features in the program in stores this month. Please vote for the Institute when you shop in Ballarat stores with your community reward tokens. Thanks to The Courier for capturing our researchers Tobias and Brendan measuring the tokens in the lab last week

09.01.2022 Today marks the start of #NationalScienceWeek, Australia’s annual celebration of science and technology. Each year over one million people participate in science events across the nation. Here at Fiona Elsey Cancer Research Institute, our doors are always open to help inspire the next generation of researchers and we love being part of science week. Check out scienceweek.net.au for some of the great online resources and stay tuned here!

09.01.2022 Visit www.fecri.org.au to see the fantastic wines on offer at our Online Wine Auction. Place your bid NOW and support cancer research!

09.01.2022 Our team’s work into liver cancer has received further endorsement. FECRI scientists Dr Prashanth Prithviraj and Dr Aparna Jayachandran have published their research on liver cancer entitled ‘Combined inhibition of TGF-1-induced EMT and PD-L1 silencing re-sensitizes hepatocellular carcinoma to Sorafenib treatment’ in the Journal of Clinical Medicine. Hepatocellular carcinoma (HCC) is a common primary liver malignancy accounting for approximately 80-90% of all liver cancers.... The global burden of HCC is increasing rapidly but treatment options are still limited with increased therapy resistance. Circumventing resistance by exploring and targeting possible molecular mechanisms and pathways contributing to resistance is needed. The current study focuses on epithelial-to-mesenchymal transition (EMT), a cellular process which confers HCC tumour cells with the ability to evade the immune system and develop resistance to treatment. The present study is the first to examine the association between cytokine transforming growth factor (TGF)-1-induced EMT, aberrant immune checkpoint expression and resistance in HCC. These findings provide a valuable strategy to potentially improve the clinical efficacy of treatment in HCC patients by utilizing a combinatorial treatment approach. This research was conducted in close collaboration with liver cancer researchers at the Gallipoli Medical Research Foundation and the The University of Queensland. Read more at www.fecri.org.au/liver-cancerpub21/ Dr Aparna Jayachandran & Dr Prashanth Prithviraj MDP Photography

09.01.2022 With a vineyard originally planted in 1870, Mount Langi Ghiran has become home to one of Australia's finest cool climate wines, the Langi Shiraz. The vineyard is one of the most isolated and unique sites in Australian viticulture, set amongst the moody backdrop of Victoria's Great Dividing Range in The Grampians. The Mount Langi Ghiran is Aboriginal for home of the yellow-tailed black cockatoo. ... In mid-2018 Adam Louder took the helm as Head Winemaker at Langi. Adam’s career began in 1998 at Langi as a cellar hand under Trevor Mast and followed onto working with chief winemaker Dan Buckle. After a career in winemaking that has since taken him around the globe, Adam returned to Langi in 2016. Drawn to Langi for its unique growing season, beautiful surrounds and like-minded team. Adam together with Damien Sheehan, Langi’s Viticulturalist, and the winemaking team share a passion and vision for Langi, now and for the future. This is a dedicated team who are on the same page; all aiming to make some of the best wines in the country. You have an opportunity to sample their Talus Shiraz and Talus Riesling as we have three duo packs available in the Online Wine Auction. Money raised goes directly to cancer research. Visit www.fecri.org.au to access the wines up for offer! Mount Langi Ghiran #wineauction #cancerresearch #winelovers

09.01.2022 I had cancer but it never had me Read Kate Gale - Author latest book ‘Thanks for the Mammaries.’ Kate was diagnosed with breast cancer aged 27 and watched her husband battle kidney cancer just 5 years later. Kate is a wife, mum, author, survivor and cancer advocate. Buy a copy of Thanks For The Mammaries by Kate Gale before the end of April, and Ocean Reeve will match every donation from the proceeds of the sale.Head to Kate’s website to purchase a book- www.kategaleauthor.com

08.01.2022 Representatives from the Buninyong & District Community Bank Branch, Creswick & District Community Bank Branch Beaufort Community Bank Branch and Ballan & District Community Bank Branch visited the Institute to see and celebrate our recently upgrade to our Tissue Bank. An upgrade to this facility was imperative for the ongoing momentum of our research interests. $200,000 of funding has been received from the Community Bank branches with assisting grants from the Percy Baxte...r Charitable Trust, James Kirkpatrick Charitable Trust and Patricia Madigan Charitable Trust for new equipment and relocation works. The Bendigo Bank Tissue Bank is a collection of human tissues that are stored as live cells in liquid nitrogen at -200C and used for research later. It is a fundamental component to our research. Our tissue bank has continued to be managed at this time and gratefully accepting and processing tissue and blood samples. The Tissue Bank houses nearly 4500 patient samples- many from cancer patients as well as healthy samples that are vital to researchers work. This resource has seen incredible 52% growth on the last year. For more on the story bit.ly/btb_20

07.01.2022 Last week Boatshed Restaurant hosted the Pink Ladies Dinner 2020 for Breast Cancer Awareness Month. It was a beautiful evening of food, friends and fundraising for breast cancer research at the Fiona Elsey Cancer Research Institute. Guest speaker was Dr Aparna Jayachandran- Lead Breast Cancer Researcher from the Institute, who shared her work and the developments in the work.... Together we raised $7000.00. Thank you to our wonderful supporters Boatshed Restaurant, @jmrssewing, Gems and Jewels, Blue Pyrenees Estate, Balloon Delights, HappyBloom, Grounded Pleasures, UFS Dispensaries Ltd @reddoorrugs, & @jennyburkeflorist

06.01.2022 This month is Breast cancer awareness month. Breast cancer is one of the most common cancers in women with 20,000 new cases diagnosed in Australia each year and second most common cause of cancer related deaths in women with over 3,100 deaths per year. ... This month presents us with an opportunity to focus on the importance of being ‘breast aware’, understanding the risk factors to help detect and treat, and shining a light on important research for the future. Our newly established Breast cancer project needs patient samples for research. Institute partner, Lake Imaging is a crucial part of the process in obtaining samples for research. Breast tissue samples are collected in biopsies, guided by ultrasound at both diagnosis and in treatment. These samples can be only collected from patients have already given consent to donate to research. The process is not an additional procedure and is done using samples collected for pathology. Samples are then stored in liquid nitrogen in the FECRI’s tissue bank to be used later. Only through research, better treatments can be found. For more information head to fecri.org.au/shining-a-light-on-research-this-october/ See more

06.01.2022 Some might say the Redman family have wine running through their veins. This fourth generation business has a fascinating history and the benefit of passing knowledge, hard work and passion from generation to the next. It started in 1908, Bill and his family purchased 16 hectares of vineyards in Coonawarra, South Australia. He sold the 1908 vintage grapes to the Riddoch winery to help pay for the block. Bill made his first wine in 1909 in very rudimentary conditions. He sol...d all the wine in bulk to other wine companies. In 1937, Owen Redman joined his father Bill in the family winemaking business. They continued to sell their wine to other wineries, however, the reputation of their wines continued to grow and demand for their wine increased. Skip forward a generation with much dedication and persistence in between. Redman Wines continued to make just two dry reds, Redman Claret (100% Shiraz) and Redman Cabernet Sauvignon, until 1992, when the Cabernet Sauvignon Merlot was introduced in limited quantities. Bruce and Winnie Redman’s son Daniel, the fourth generation of the Redman family to make wine in Coonawarra, joined the family business in 2008, exactly 100 years after his great grandfather made his first wine. Dan's younger brother Michael joined the business in 2015. Today, the Redman family continues to grow grapes and make wine in the traditions initiated by Bill Redman 100 years ago, and with the next generation in place, this tradition and family success look certain to continue for years to come. Redman Wines have generously donated many bottles from their collection to our Online Wine Auction. Have a look if there are any you fancy at www.fecri.org.au Redman Wines #wineauction #cancerresearch #winelovers

06.01.2022 Following from our previously published results, our colorectal research group of Professor Stuart Berzins, Professor George Kannourakis, Federation University Australia Dr Morgan Wallace and PhD candidate Jason Kelly, have recently published a review, detailing the current state of knowledge about the role of MAIT cells have in the cancer. This paper includes their likely influence when activated, potential sources of stimulation in the tumour and prospects for MAIT cells being used in clinical settings as markers or targets for new immunotherapies. A Role for MAIT Cells in Colorectal Cancer. Frontiers in Immunology. Link to paper frontiersin.org/articles/10.3389/fimmu.2020.00949/full

05.01.2022 Our research output continues to increase momentum and our results are recognised. Our team have published 45 + peer-reviewed papers in the last 5 years; 24 of those in the last 2 years. The publication of our research cements the relevancy and importance of our work.... Recent results include: Bowel cancer research team reported discovery of a subset of immune cells in the bowel, that can misbehave and release chemical messengers that promote cancer and inhibit other immune cells. The different origins of high-grade serous Ovarian cancer and a novel new treatment strategies using an inhibitor drug to target a protein called Magmas in assisting to combat chemo resistance in treatment. The role of immune cells in rare cancer Langerhans cell histiocytosis Donate at fecri.org.au to support the continuation of our important work.

05.01.2022 Like many organisations and businesses, we are continuing to navigate our way through the major social and economic impact of COVID-19. Each day 396 Australians are diagnosed with cancer. Cancer is not elective. Diagnosis and treatments are improving all the time, but we must continue our part in researching for a cure. The Institute is committed to ensure the momentum of our research continues at this uncertain time. Our researchers in the last year, have had outcomes in o...ur Bowel cancer, Ovarian and Histiocytosis work. We look forward to sharing further exciting breakthroughs in other projects with you shortly. We and our wonderful volunteers, have had to cancel all planned fundraising events for the forseeable future. We are extremely grateful to all that donated to our annual appeal but we still need the continued support of the community to ensure our future. If you or your business is able to make a tax deductable donation, please consider the Fiona Elsey Cancer Research Institute. To donate please visit our secure website fecri.org.au or call (03) 53313101 for a confidential discussion with our Fundraising and Gift team.

05.01.2022 Thank you to the Surf Coast Times for sharing the Lighthouse Classic 'Shine A Light on Cancer' - 1- 31Jan 2021 event and the story behind it. Pictured below (left to right) our own Professor George Kannourakis, Surf Coast Mayor, Libby Stapleton, and event organiser Janet Jones. It isn't too late to register to get involved and take a walk in support of cancer anytime this month. Simply walk or run along the beautiful 12km route Great Ocean Road from Urquhart Bluff, to Aireys... Inlet Lighthouse or choose your own local destination, maybe even a lighthouse, anytime during the month of January. For more information and on how to register visit fecri.org.au/fundraiser/lighthouse-classic/ Proudly sponsored by A La Grecque, Eagles Nest Fine Art Gallery, Aireys Inlet ,Register Now, Ocean Inlet &Yeux Apparel.

04.01.2022 Put your lockdown fitness to the test this January and in doing so help fight cancer. Simply walk or run along the beautiful 12km route Great Ocean Road from Urquhart Bluff, to Aireys Inlet Lighthouse or choose your own local destination, maybe even a lighthouse, anytime during the month of January. For more information and on how to register visit fecri.org.au/fundraiser/lighthouse-classic/... Proudly sponsored by A La Grecque, Eagles Nest Fine Art Gallery, Aireys Inlet , Register Now, Ocean Inlet, Yeux Apparel.

03.01.2022 The Institute like all of us, has had to adjust to the current conditions. This is our team having our now virtual weekly team meeting today. Cancer is not elective, and we want you to know that our research continues. We have modified our workplace to responsibly comply with Government directions. Some of the team are working from home, some are in the lab doing experiments- we have not stopped.... Today on Zoom we celebrated the boss’s birthday, and the amazing achievements of our team. In the last 4 months, our researchers have published an amazing 7 papers highlighting some great results from our research. Stay tuned we will share these with you over the coming weeks!

03.01.2022 Breast cancer is one of the most common cancers in women with 20,000 new cases diagnosed in Australia each year and the second most common cause of cancer related deaths in women October is Breast cancer awareness month and it presents us with an opportunity to focus on the importance of being ‘breast aware’, understanding the risk factors to help detect, treat, and shining a light on important research for the future. Our Breast cancer project commenced in March of this year..., made possible after seed funding from a private philanthropic donation in late 2019 and this February’s Ballarat Cycle Classic that raised a record $300,000 for the project. This team is investigating the immunology of breast cancer with special reference to high risk triple negative breast cancer. This research aims to determine protein targets on breast cancer cells that may be involved in evading the immune system, by creating a camouflaging fog around these cells. It is hoped that by identifying these proteins, druggable targets can be developed that would lift the fog from these cells and allow the immune system to attack the cancer. This work is currently being undertaken at the Institute with other cancers such as, Chronic lymphocytic leukaemia (CLL) and Ovarian cancer. Triple negative breast cancer accounts for 15% of all breast cancers Since commencing the team already published world first work first relating to aggressive triple-negative breast cancer, which it is hoped, will lead to a potential therapeutic target that will improve treatment. To find out more about our research or to donate please head to fecri.org.au See more

03.01.2022 Join in a fundraising night at home for cancer research. Head to UnGala - You're Not Invited to Attend or fecri.org.au for more information. Kindly sponsored by McCain Foods Australia.

03.01.2022 Jim and his Allsorts team have been riding in the Murray2Moyne since early this morning. Reports from the support crew is they are doing well. We’re eagerly cheering them on and are in awe of their commitment and passion. ... Watch Jim’s story here and support this incredible achievement today! Jimmys Licorice Allsorts

02.01.2022 For more information on our research and how you can support, visit fecri.org.au.

01.01.2022 The Community Bank Tissue Bank is absolutely vital to our research program. Over 4500 cancer patients have donated samples to directly assist our research, and doing so are directly contributing to better trreatment outcomes in the future. If you would like more information regarding donating to our tissue bank, please speak to your medical professional or alternatively contact us on (03) 53313101. Thank you #9News

01.01.2022 Please join us on Sunday 28 March for a very special long lunch at @the_sharedtable Buninyong. This is in support of the wonderful fundraising efforts of the @lighthouseclassic21 for cancer research. @the_sharedtable @sherwagyu, @westernplainpork and @natures.cargo have come together to create a beautiful 5 course luncheon paired with local wines -$160pp. An event not to be missed. To book please go to, the @the_sharedtable website. @the_sharedtable

01.01.2022 Do you have a budding scientist doing home learning? Check out the great DIY Science projects to try at home. Perfect if you can't get out this #NationalScienceWeek