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25.01.2022 Stress, genetics and anxiety. Defining the complex interaction between stress and the epigenome and the development of anxiety. https://genhx.com/2019/01/16/699/

24.01.2022 This is an interesting perspective on the $2 million dollar gene therapy drug for spinal muscular dystrophy. In the past, pharmaceutical companies have not been able to make cures for genetic diseases due to the cost involved in drug development and clinical trials etc. The money they get in return for the treatment needs to cover the expenses and some. The rarer the disease and the least amount of people who require it, the more expensive it has to be. However, now with recent advances in genetics and the many ways in which the genome can manipulated both naturally and synthetically, the future for all disease looks extremely bright. https://www.statnews.com//spinal-muscular-atrophy-zolgens/

23.01.2022 All environmental substances have the ability to negatively impact the epigenome and cause changes to genes associated with neuro-inflammation. The degree of neuro-inflammation from these chemicals comes down the individuals genome. The impact on the individual is where the research money needs to go.

22.01.2022 Personalised medicine is the future for all disease.

22.01.2022 Methylation blocks gene expression. Acetylation allows gene expression. Unnecessarily treating methylation can lead to blocked expression of essential genes. Hypermethylation for me = low serotonin and low GABA, not a fun combination. #StopBlockingMe #ThinkBeforeYouMe #methylation #methylfolate #hypermethylation #acetylation #anxiety #speakevenifyourvoiceshakes #doitfordolly #depression #beyondblue #nutritionalmedicine #functionalmedicine #genetics #geneticmodulation #mthfrawareness

19.01.2022 Ultraviolet exposure to the skin, causes hyper-methylation of tumour suppressor genes. Dietary bioactive compounds such as ECGC in green tea can reduce methylation and prevent skin cancer. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288155/

18.01.2022 Single gene mutations causing disease are rare, it is the combination of gene - gene interactions that explain the majority of diseases. #epigenetics #genetics #genegeneinteractions #health #disease #chronicdisease #mutation https://t.co/jIeS1kDhii

18.01.2022 Podcast 2. Check it out! What is epigenetics? What is the epigenome? How does epigenetic knowledge, advance personalised medicine? What does epigenetic knowledge mean for the future of medicine? ... Epigenetic modulation by internal and external substances. Epigenetic modulation of the menstrual cycle. https://m.soundcloud.com/user-35522/podcast-2-the-epigenome

18.01.2022 Researchers discovered over 1 million species are facing extinction. One of the driving forces of extinction is the differential methylation patters from exposure to environmental contaminants. Bpa causes differential methylation patterns in essential but sometimes tumour promoting genes such as the estradiol receptor.

17.01.2022 Natural genetic modification doesn't permanently change your DNA like dangerous GMO foods, but rather gently nudges the epigenome in areas needing attention to wake up problem genes. Personalised medicine is the only true way forward for healthcare, especially for chronic diseases.

16.01.2022 Avoid locking your genome. Know your methylation status.

16.01.2022 I have been asked to share some insight into why children are less effected by the Coronavirus than adults. As we age, we gradually increase whole body DNA met...hylation. Methylation turns off gene expression by adding a methyl group to the genes promotor region on the DNA. The epigenetic profile of a child, supports heavy immune system activation and antibody production as they are still building their immunity. Us adults, have been exposed to many more environmental chemicals, foods and things that promote methylation and ultimately our resistance is much lower. Other Coronaviruses such as SARS and MERS, use methylation for entry into the cell, blocking hosts IFN-y expression and to increase replication. Some practioners are still recommending B vitamins, I would advise against that. Also avoidance of fortified breads and flours. I hope that has clarified a few things for you.

15.01.2022 Careful attention must be paid to your epigenetic status, especially in patients with a family history of cancer. Over methylating can lead to silencing of many genes including essential tumour suppressor genes. Whole exome sequencing provides a complete view of the entire coding region of the genome, to ensure you don't accidentally overmethylate. ... https://www.nature.com/articles/1205600 #methylation #mthfrexperts #mthfr #acetylation #geneticmodulation #cancer #cancerawareness #chronicdisease #chronicillness #health #functionalmedicine #nutritionalmedicine #nutrigenomics

15.01.2022 GenHx provides a superior add on service for your patients personalised treatment plan. Cherry-picked SNP analyses tell us nothing useful when it comes to the treatment of chronic diseases where as the GenHx whole exome sequencing looks at the entire coding region of the genome and provides all the genomic information essential for chronic disease resolution. Your patients data is held 100% anonymously and confidentially, and we promise to never sell your data off to big ph...arma...never! Each whole exome sequencing analysis purchased includes 12 Months of unlimited practitioner support, to ensure your patients customised treatment maintains superior quality.

15.01.2022 The hype surrounding methylation, and genes associated with methylation, such as MTHFR mean very little, without looking at the entire genome. Check out my blog debunking methylation and MTHFR. Please share if you know someone who could be unnecessarily treating methylation. It may just save them a life of ill health. https://genhx.com//05/misconceptions-mthfr-and-methylation/

14.01.2022 Methylation; the old and the new. http://genhx.com/2018/07/03/methylation

13.01.2022 I have been swamped in forums recently with questions in regards to how an excess of methylation can contribute to depression, anxiety, OCD, paranoia etc. Ther...e are many ways in which this can occur but this particular pathway confuses us the most. We are under the impression that taking folate is essential for BH4 synthesis and ultimately serotonin synthesis etc. This is not the case, in fact taking L-methylfolate is more likely to have the opposite effect.

13.01.2022 Are you a health practitioner; specialising in chronic disease, and don't know where to start with the rollout of epigenetic personalised medicine? Purchase a genetic analysis package for your patient and have access to 12 months of ongoing practitioner support. For a limited time only, quote "Epigenetics" to receive 10% off our whole exome sequencing package, the most advanced, comprehensive genomic testing available today. ... #naturopath #nutritonist #functionalmedicine #practitionersupport #genetics #epigenetics www.genhx.com/nutrigenomic-training

11.01.2022 All epigenetic modifications are essential. Focusing solely on methylation is not the answer and will result in turning essential genes off.

10.01.2022 Glyphosate changes gene expression through changing DNA methylation patterns. Please sign.. Our children shouldn't be exposed to this toxin!

10.01.2022 Advanced genome sequencing, can detect hypermethylatiom, gene expression and deletions of any gene in the gastrointestinal tract.

10.01.2022 Brief definition of the educational system these days!

09.01.2022 Small changes to your genome can be the result of chronic stress or environmental insult. The changes can lead to a disruption of key immune cytokines and a loss of self tolerance. https://wordpress.com/post/genhx.com/348

08.01.2022 Loss of Function Analysis of Pathogenic Epigenetic Modifying Genes; Causing Intellectual Disability and Autism, Exhibit a Common Neuronal Network of a Hyperactivity Phenotype.

08.01.2022 Upregulation of TIA1 attenuates fear memory in a murine model of PTSD. What makes this even more interesting is; mutations in this gene are associated with myopathy. This gene is essential for the downregulation of major inflammatory cytokines such as IL6 and TNFa. This is seen in models of endometriosis and arthritis. https://www.sciencedaily.com/releas/2019//190312170807.htm

06.01.2022 Discover ways to boost your immunity with whole genome sequencing.

04.01.2022 Harvard University discovers gene responsible for limb regeneration. https://news.harvard.edu//harvard-study-unlocks-a-key-to-/

04.01.2022 This is really cool! I have been reading a lot about people with CCR5 mutations are resistant to HIV. It was only a matter of time before they gave stems cells from people with these mutations to HIV patients. People also carry mutations that make them resistant to experimental auto-immune disease. Genetics holds the keys to everything. Bring on the age of genetics! https://www.sciencemag.org//has-second-person-hiv-been-cur

04.01.2022 For trauma to cause epigenetic changes and result in anxiety and PTSD doesn't always have to be tragic. https://genhx.com/2019/01/31/trauma-is-trauma-baby/

03.01.2022 I am a member of many CFS groups due to my 15 year history with the syndrome. And I worry as there is so much misinformation circulating in regards to management for CFS. Some of my patients have previously be recommended methylated B vitamins, zinc and vitamin D. All of of these vitamin types can be detrimental to the immune health of someone with CFS. This is because acetylation promotes gene expression, where methylation blocks it. This study shows that hypo-acetylation c...ontributes to post exertion malaise. In fact hypo-acetylation plays a huge part in CFS. B vitamins and Zinc both cause hypo-acetylation. https://www.mdpi.com/2075-4418/9/3/70/htm Vitamin D is anti-inflammatory and CFS sufferers are stuck in an anti-inflammatory state as a result of hypo-acetylation and others.

02.01.2022 The coronaviruses have showed delayed interferon stimulation and significant inhibition of expression of a specific set of interferon stimulated genes in the ho...st. The viral manipulation of the host cells epigenetic machinery, results in successful viral infection and viral replication by Coronaviruses. The Coronaviruses have evolved a antagonist mechanisms to overcome interferon stimulated genes. With SARS-COV increasing histone 3 lysine 4 methylation and repressing histone 3 lysine 27 methylation whereas MERS-COV increased Histone 3 lysine 27 methylation and reduced histone 3 lysine 4 methylation. Either way, increasing methylation increases pathogenicity of the Coronaviruses. https://www.ncbi.nlm.nih.gov/pubmed/28212305 Epigenetic Tips for Coronavirus invasion. - Check with your Dr before self-administering anything. - Avoid - methylation enhancing supplements or vitamins. - Avoid - leafy greens, alcohol, fermented beverages and foods. - Avoid - powerful anti-inflammatory foods Fish oil, vitamin D, omega 3, garlic and ginger. - Avoid fortified flours, bread, cake, wheat, biscuits. Consume More - - Vitamin C is a powerful demethylator. Liposomal vitamin C, bypasses the gastrointestinal tract and is far more efficient in protection against viral infection that oral vitamin C. Vitamin C may help prevent DNA methylation, histone methylation and the formation of heterochromatin. Red, orange and yellow foods, capsicum, tomato, pineapple, chilli, citrus fruits etc. - High protein - low methyl group diet. Animal protein with each meal. Animal proteins contain powerful immune stimulants. - Bone Marrow contains constituents capable of reversing the effects of histone methylation and contains many immune stimulants. - Whey Protein Contains immunoglobulins. - Some medicinal mushrooms and their metabolites are immune stimulants. (Beta-glucan). Dont overdo these, as some contain lots of folate. - Keep some hand sanitiser with you. - Diffuse some tea tree oil, in a group setting/work place.

01.01.2022 Researchers find superhero gene.

01.01.2022 Compounds found in green tea and carrots completely reversed working memory related symtoms in experimental mice with Alzheimer's Disease after only 3 months. https://t.co/jP8U7Xfll3

01.01.2022 Allergies to mites including this little guy, can be associated with rosacea.