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25.01.2022 Melbourne #millionmaskmarch 2019 !

24.01.2022 Shout out to anyone who has Epilepsy and uses or wants to use Cannabis for seizure reduction. Epilepsy Action Australia are the only national organisation that not only provides support to people who have Epilepsy and their families, schools and communities, but also advocates for better access to affordable medical cannabis products for Epilepsy. Give them a like and consider supporting their Purple Project!

17.01.2022 If you're in Queensland, put your internet ink to good use and sign!

03.01.2022 Cannabis as a Cure for Cancer. Written by: Bonni Goldstein, M.D., 2016. "Cannabis as a cure for cancer is a controversial topic. Since cannabis is classified a...s a Schedule I controlled substance, research on the anticancer properties in human clinical trials has been prohibited. As of the writing of this book, there is one published human trial on cannabis use as an anticancer compound with a second trial in progress (both in Europe). There exists, however, a significant body of scientific research that shows both THC and CBD have anti-cancer properties in certain cancers. Both compounds have been shown to cause cancer cells to commit suicide (called apoptosis), inhibit tumor growth, inhibit metastasis and cancer cell migration, and inhibit angiogenesis, which is the growth of blood vessels that feed tumors. [17,18] Additionally, recent research has also shown that phyto-cannabinoids can work synergistically with certain chemotherapies to enhance the anticancer effects. The following is a short list of recent research that documents the anticancer effects of cannabinoids. This is by no means a complete review of the scientific literature as there are thousands of articles that have been published in the last two decades exploring the potential of cannabis as an anticancer agent. It is important to note that these are not human trials: - THC resulted in the activation of autophagy (cell self-digestion), loss of cell viability, and activation of apoptosis of melanoma cells. [19] - Combining the chemotherapy drug gemcitabine with cannabinoids synergistically and strongly inhibited growth of human pancreatic tumor cells grafted in mice without apparent toxic effects. [20] - CBD induced cell death of breast cancer cells through receptor independent mechanisms. [21] - CBD significantly reduced primary tumor mass as well as the size and number of lung metastatic foci in two models of metastasis, and CBD inhibited human breast cancer cell proliferation and invasion. [22] - Synthetic cannabinoids that bind to Type 1 and Type 2 cannabinoid receptors were given to mice with non-small cell lung cancer with the results of reduced proliferation and vascularization, and increased apoptosis of cancer cells. [23] - THC was found to decrease cell proliferation and increase cell death of human glioblastoma multiforme cells. [24] - THC induces apoptosis in colorectal cancer cells through activation of the CB1 cannabinoid receptor. [25] - THC is a potent inducer of apoptosis in three leukemic cell lines at low concentrations and as early as six hours after exposure. [26] - CBD was found to increase the uptake of certain chemotherapeutic agents by malignant glioma cells, increasing the effectiveness of the chemotherapy. [27] - In the only published human trial, researchers in Spain directly administered THC into glioblastoma multiforme cancer cells in terminal patients and found that it inhibited tumor cell proliferation without any adverse side effects. [28] Because cannabis remains federally illegal in the United States, research in humans is prohibited. However, in states that have legalized medical cannabis, many desperate cancer patients are using cannabis not only to treat symptoms, but also to treat the cancer directly. There are thousands of anecdotal reports of cancer patients using concentrated cannabis oils containing THC or CBD or both resulting in complete resolution of cancer. Cannabis for cancer treatment is not FDA approved nor is it considered standard of care by regulatory medical boards. However, patients who are not responding to standard cancer treatment are seeking it as an alternative therapy. The main concerns for these patients are dosage, whether to take CBD or THC or both, and the duration of treatment. All of these questions remain unanswered and continue to be a roadblock to those seeking life-saving cannabis therapy. As a cannabis physician I have many patients use concentrated cannabis oil for cancer treatment, with or without conventional chemotherapy and/or radiation. Some of my patients have had incredible results with complete resolution of the cancer. A number of my patients with advanced cancers who were told that they only had a few months to live are living months or years beyond their prognosis. I believe that cannabis treatment can extend life and possibly cure cancer when given early in the course and in relatively high doses. Although I am overjoyed when my patients improve, as a scientist I am quite frustrated by the lack of research. We must find the answers to these crucial questions so that patients who are suffering with aggressive and advanced cancers can have cannabis therapy as an option. If research on dosing, duration of treatment and cannabinoid profile to treat specific cancers can be performed, we will be able to use cannabis as a non-toxic chemotherapy and save lives." Sources: [17] Velasco, Guillermo, et al. The use of cannabinoids as anticancer agents. Progress in Neuro-Psychopharmacology and Biological Psychiatry 64 (2016): 259-266. [18] Ramer, Robert, and Burkhard Hinz. Chapter Two-New Insights into Antimetastatic and Antiangiogenic Effects of Cannabinoids. International review of cell and molecular biology 314 (2015): 43-116. [19] Armstrong, Jane L., et al. Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. Journal of Investigative Dermatology 135.6 (2015): 1629-1637. [20] Donadelli, M., et al. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell death & disease 2.4 (2011): e152. [21] Shrivastava, Ashutosh, et al. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Molecular Cancer Therapeutics 10.7 (2011): 1161-1172. [22] McAllister, Sean D., et al. Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast cancer research and treatment 129.1 (2011): 37-47. [23] Preet, Anju, et al. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of nonsmall cell lung cancer growth and metastasis. Cancer Prevention Research 4.1 (2011): 65-75. [24] Mc Allister, Sean D., et al. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of neuro-oncology 74.1 (2005): 31-40. [25] Greenhough, Alexander, et al. The cannabinoid 9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. International journal of cancer 121.10 (2007): 2172-2180. [26] Powles, Thomas, et al. Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood 105.3 (2005): 1214-1221. [27] Nabissi, Massimo, et al. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 34.1 (2013): 48-57. [28] Guzman, M., et al. A pilot clinical study of 9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British journal of cancer 95.2(2006)