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25.01.2022 Fraud & Misconduct in Clinical Research ABSTRACT Fraud and misconduct in clinical research is widespread. Good clinical practice is a guideline adopted interna...tionally as standard operating procedure for conduct of clinical research. . Despite these guidelines being available, unavailability of internationally harmonized framework for managing research fraud and misconduct makes clinical research a highly vulnerable area to commit fraud. Fraud could be of various types and due to various reasons. Whatever the circumstances be, any fraud should be dealt with strictly and regulations should be in place to prevent its occurrence INTRODUCTION Scientific fraud reappears with alarming consistency from paleontology to nanotechnology. Several studies have found that more than 40% of surveyed researchers were aware of misconduct but did not report it. Sheehan et al. reported in 2005 that 17% of surveyed authors of clinical drug trials reported that they personally knew of fabrication in research occurring over the previous 10 years. . Quality at sites is usually judged by audits and inspections. There has been as high as 23% (official action indicated) for cause inspections conducted by US Food and drug Administration (USFDA) over the last several years. These kinds of results indicate that there exists a substantial problem. Fraud/misconduct can lead to study losing its entire credibility. Moreover, it can lead to ineffective or harmful treatment being available or patients being denied of effective treatment. This article discusses the difference between fraud and misconduct, the possible reasons for the occurrence of the same and explores options, which can possibly help prevent such instances. WHY DOES ANYONE COMMIT FRAUD/MISCONDUCT? . Reasons for fraud/misconduct in clinical Research could vary from personal to professional. Fraud could be a result of professional over ambition to become famous, a gain in prestige by being a part of international clinical trials or for financial interests. At times it could be due to laziness of the researcher or site staff for complex studies needing repeat assessments e.g., repeat blood pressure measurements, Blood pressure rounded off to nearest 5 mm, timed spirometry assessments. At times, misconduct also results when an investigator strongly believes intuitively in the right answer despite the available evidence being contrary. . Misconduct could also be due to innocent ignorance like backdating the subject's signature on a consent form because the subject forgot to date the form initially or discarding source documents after accurate transcription or even creating source documents from case record forms. Pressures for promotion and tenure, competition amongst investigators, need for recognition, ego, personality factors and conflicting personal and professional obligations are some factors, which can influence certain individuals to involve in fraud/misconduct. There could also be associated environmental factors such as amount of oversight of the study, existence of explicit versus implicit rules, penalties and rewards attached to such rules, extent of training imparted, regulations involved and insufficient mentoring ~ ~ ~ Article -> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700330/ ~ ~ ~ #Covid #Healthy #Health #MentalHealth #HealthyLiving #MedicalTourism #MedicalSpa #Medical #MedicalField #MedicalEducation #CancerResearch #Researcher #ClinicalResearch #ScientificResearch #MedicalResearch #Yoga #YogaInspiration #Keto #KetoLife #FunctionalTraining #FunctionalMedicine #FunctionalNutrition #Vegan #VeganLife #Paleo #Ancestral #Nutrition #Nutritionist #DigestiveHEalth #LeakyGut #GutHealth #InjuryNutrition

23.01.2022 This is because specific types of RED LIGHT actually stimulate the bodies repair process... so why not try the red light therapy FIRST since after all theres hundreds of published studies on the topic showing it can reduce pain & depression, improve joint health & much more... :) Enjoy, Nutrition Coach Chris #InjuryNutrition ... https://www.newscientist.com//2242443-red-light-could-be-/

21.01.2022 "Scientists have connected these devices to a higher risk of developing a rare cancer of the immune system and inflammatory reactions, particularly for women with a family history of autoimmune conditions. Meanwhile, thousands of patients have complained of fatigue, brain fog, and other problems following implantation."

14.01.2022 Hope everyone is having a happy festive season Remember to reach out to someone who may not have family nearby

11.01.2022 "... Life as entanglement Scholars such as Timothy Morton and Bruno Latour remind us that viewing the natural world as separated from humans is not only ethically problematic but empirically false. Microorganisms in our gut aid digestion, while others compose part of our skin. Pollinators such as bees and wasps help produce the food we eat, while photosynthetic organisms such as trees and phytoplankton provide the oxygen that we need in order to live, in turn taking up the ca...rbon dioxide we expel. In the Anthropocene, we are seeing more and more how the fates of humanity and nature are intertwined. Governments and corporations have developed such control over the natural systems they exploit that they are destabilising the fundamental chemistry of the global climate system. As a result, inhospitable heat, rising seas, and increasingly frequent and extreme weather events will render millions of humans and animals refugees. Reconnecting the dots The good news is that the perceived separation from nature is not universal among the planet’s human inhabitants. Australian, Amerindian, and countless other indigenous belief systems often portray nonhumans as kin with intrinsic value to be respected, rather than external objects to be dominated or exploited..." https://theconversation.com/humanity-and-nature-are-not-sep

10.01.2022 Arthritis can be aggravated by certain metabolic by products like uric acid... Increasing hydration, electrolytes & certain antioxidant compounds found in fruits & veggies can help speed their elimination & provide relief. Heres just a few good ones to include in your regimen ;) ... Enjoy, Nutrition Coach Chris (Nutritional Medicine) https://www.msn.com//fruits-to-eat-to-reduce-/ar-BB16tE5k

09.01.2022 "More than 600 of the nation’s physicians sent a letter to President Trump this week calling the coronavirus shutdowns a mass casualty incident with exponentially growing negative health consequences to millions of non COVID patients. The downstream health effects...are being massively under-estimated and under-reported. This is an order of magnitude error," according to the letter initiated by Simone Gold, M.D., an emergency medicine specialist in Los Angeles..."

08.01.2022 How much seafood should pregnant mothers eat? Research published in JAMA further confirms the importance of moderate seafood intake for natal development, with ...2-3 serving a week conferring long term health beneifits... ...however more than this had negative consequences, perhaps due to excess mercury exposure. I personally recommend consuming smaller seafood such as sardines that have not reached a larger size thus bioaccumulating potential toxins. "Fish is an important source of nutrients, and its consumption should not be avoided, said NIEHS grantee Leda Chatzi, M.D., Ph.D., as quoted in a March 16 press release from the University of Southern California (USC). Chatzi is from the USC Keck School of Medicine and senior investigator on the study. But pregnant women should stick to one to three servings of fish a week as recommended, and not eat more, because of the potential contamination of fish by mercury and other persistent organic pollutants. Enjoy, Nutrition Coach Chris https://factor.niehs.nih.gov/2020/5/papers/fish/index.htm

06.01.2022 "In the first big research scandal of the COVID-19 era, The Lancet and The New England Journal of Medicine (NEJM) today retracted two high-profile papers after a company declined to make the underlying data for both available for an independent audit, following questions being raised about the research. The Lancet paper, which claimed an antimalarial drug touted by President Donald Trump for treatment of COVID-19 could cause serious harm without helping patients, had had a gl...obal impact, halting trials of one of the drugs by the World Health Organization (WHO) and others. Three authors on the Lancet paper requested the retraction, after initiating an independent review of the raw hospital patient data summarized and provided by Surgisphere, a small Chicago-based company operated by Sapan Desai, the fourth author of the study. Desai had previously said he and his co-authorscardiac surgeon Mandeep Mehra of Harvard University and Brigham and Women's Hospital, Frank Ruschitzka of University Hospital Zürich, and Amit Patel, an adjunct faculty member at the University of Utahwere getting such an audit of the data, but the agreement apparently fell apart."

06.01.2022 Stress compounds most underlying physiological responses... If you have an infection, digestve issues or inflammation, for example... chronic stress tends to ma...gnify the outcomes... manage your stress & you can get away with more ;) Simple habits like deep breathing, getting adequate rest, eating nutrient dense foods such as liver thats high in B vitamins & using calming herbs such as Tulsi, Chamomile, Lavender or Ashwagandha (just to name a few), can greatly reduce your stress response, especially when done in combination. Enjoy, Chris Bellanger Nutritionist Performance Coach Researcher ~ ~ ~ ~ ~ ~ "People with recent heart attacks have significantly higher activity in the amygdala, the brain area involved in stress perception and emotional response, along with greater inflammation in arteries resulting from increased bone marrow activity, a hallmark of plaque build-up -- and these are all capable of returning to near-normal, according to preliminary research presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2020. The meeting is a virtual event in 2020, to be held May 5-7, and is a premier global exchange of the latest advances in new and emerging scientific research in arteriosclerosis, thrombosis, vascular biology, peripheral vascular disease, vascular surgery and functional genomics. "The results of this study advance our understanding of the interconnections among the brain, bone marrow and blood vessels, with activity of the brain emotional center closely linked to heart disease activity and inflammation of blood vessels which are spurred by inflammatory immune cells produced by the bone marrow," said Dong Oh Kang, M.D., lead study author and clinical instructor in the cardiovascular center of Korea University Guro Hospital in Seoul, Korea. The researchers obtained simultaneous PET and CT scans to create 3-D images of the brain, major arteries and bone marrow of 62 study participants. The study included 45 people (84% male, average age 60 years) who had a heart attack within the previous 45 days and 17 people with no heart attack history (76% male, average age 59.6 years), the control group. All participants completed widely accepted standard screening questionnaires for depression and perceived stress. Researchers found: Those who had a recent heart attack had significantly higher activity in the amygdala region of the brain, which is responsible for stress perception and emotional response. The participants who had a recent heart attack also had increased inflammation in the aorta and carotid artery (neck), which supplies blood to the brain, and increased bone marrow activity, indicating active production of inflammatory cells. In both groups, those who reported feeling more depressed or stressed on psychological questionnaires showed higher activity in the amygdala..." https://www.eurekalert.org/pub_re/2020-05/aha-bea043020.php

04.01.2022 Launch special Immune & Antioxidant Superfood 55% Certified Organic ... 25% Wild Australian Kakadu Plum (World's highest food source of Vitamin C plus antioxidants) 37.5% Wild Harvested Australian Made Special: AUD$19.95 + P&H First 20 orders only! RR $34.95

03.01.2022 This is SO CRITICAL TO UNDERSTAND... those of us who were fortunate enough to be born into a supportive family with a house, job, good food & education, please consider that YOUR SUCCESS WAS IN LARGE PART JUST LUCK & GOOD ENVIRONMENT Those who volunteer in any capacity or try to give back to society & recognize their good fortune, THANKOU Those that look down on people born into less fortunate circumstances need to do some serious soul searching & start giving back... Th...ese people are at least in part simply victims of a less optimal environment "Numerous studies have shown that children who grow up in more deprived neighbourhoods tend to have worse physical health as adults compared to those raised in more affluent areas. This is the case even when researchers take into account family income and education, and whether or not parents have major illnesses. In order to address this health disparity, researchers need to understand how those living in disadvantaged neighbourhoods end up with worse health outcomes. Our team's latest study has highlighted one potential way your childhood neighbourhood may influence your health for years to come. It might do so through changing how the activity of your genes is regulated. Gene regulation or "epigenetics" is the process of turning on or off genes. It's an important part of how our bodies develop over time. For instance, a certain group of genes are turned on to increase hormone production during puberty. We call the set of ways that your genes are regulated your "epigenome". We found that children who were raised in communities marked by more economic deprivation, physical dilapidation, social disconnection and danger, displayed differences from their peers in their epigenomes. This was in comparison to those who grew up in well-off neighbourhoods, which had cleaner air and were more socially connected, safe and well looked after."

02.01.2022 Nutritional Medicine, SImple but Powerful. Need some support? Message me ;) ... Chris Bellanger Nutritionist Performance Coach Researcher

02.01.2022 ZINC !!! . *** Upcoming #Melbourne #InjuryNutrition Seminars @ Prana House & JING Healthcare - See above! *** . The pathological effects of zinc deficiency include the occurrence of skin lesions, growth retardation, impaired immune function & compromised wound healing.... . Zinc is important for human health & disease due to its critical roles in growth & development, bone metabolism, the central nervous system, immune function & wound healing. Zinc is a vital cofactor for the function of more than 10% of the proteins encoded by the human genome. Zinc-dependent proteins play numerous indispensable roles within cells, such as transcriptional regulation, DNA repair, apoptosis, metabolic processing, extracellular matrix (ECM) regulation & antioxidant defence. . Zinc is especially important in skin. Skin contains a relatively high zinc content, primarily associated within the epidermis. Due to its abundance in the epidermis, mild zinc deficiency is noted to lead to roughened skin & impaired wound healing. . Zinc deficiency has been linked to delayed wound healing & low serum zinc levels have been reported in critically ill patients within Intensive Care Units. The benefits of supplemental zinc have been documented in critically ill patients, severe burn injury, subcutaneous abscess, minor surgery & pressure ulcers. . Wound healing, inflammation & immune response are intimately associated with one another. Over the years zinc has been shown capable of modulating both innate & adaptive immune functions. . Zinc in wound healing modulation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793244/ . #EatClean #Coach #Diet #FitnessLife #Muscle #SelfMotivation #Transformation #ChronicPain #Fibromyalgia #Arthritis #Inflammation #AntiInflammatory #NutritionFirst #NaturalHealth #Autoimmune #Paleo #Keto #KetoFriendly #NutrientDense #LetFoodBeThyMedicine #HolisticLiving #NaturalCures #FoodForFuel #BetterChoices #Rehabilitation #Inflammation #Diabetes #Yoga See more

02.01.2022 Effects of Sesame Seed Supplementation on Clinical Signs and Symptoms in Patients With Knee Osteoarthritis International Journal of Rheumatic Diseases - 2013 Me...thods: Fifty patients with knee OA referred to the only specialty and subspecialty orthopedic centers in the north-west of Iran, were selected and divided into two groups, namely control and sesame groups. Twenty-five patients in the control group received standard treatment while 25 patients in the sesame group received 40 g/day sesame by oral administration during 2 months of the study along with standard drug therapy. The KOOS Questionnaire, Timed Up and Go (TUG) and Visual Analog Scale (VAS) tests were used for clinical assessments. Results: There was significant difference in pain intensity between the two groups (P = 0.004) after treatment. The mean score of the KOOS Questionnaire in both treatment and control groups was significantly increased (P = 0.001 and P = 0.001, respectively) compared with baseline. The mean score of the TUG Questionnaire in both treatment and control groups was significantly decreased (P = 0.001 and P = 0.001, respectively) compared with baseline. There was significant difference in post-treatment scores of the KOOS Questionnaire (P = 0.009) and TUG (P = 0.002) between the two groups. Conclusions: The present study showed a positive effect of sesame in improving clinical signs and symptoms in patients with knee OA and indicated the fact that sesame might be a viable adjunctive therapy in treating OA. Research -> https://pubmed.ncbi.nlm.nih.gov/24164846/ #Healthy #Health #MentalHealth #HealthyLiving #MedicalSpa #Medical #MedicalField #MedicalEducation #CancerResearch #Researcher #ClinicalResearch #ScientificResearch #MedicalResearch #Yoga #YogaInspiration #Keto #KetoLife #FunctionalTraining #FunctionalMedicine #FunctionalNutrition #Vegan #VeganLife #Paleo #Ancestral #Nutrition #Nutritionist #DigestiveHEalth #LeakyGut #GutHealth #InjuryNutrition

01.01.2022 "...Citing this large body of research, more than 240 scientists who have published peer-reviewed research on the biologic and health effects of nonionizing electromagnetic fields (EMF) signed the International EMF Scientist Appeal, which calls for stronger exposure limits. The appeal makes the following assertions: Numerous recent scientific publications have shown that EMF affects living organisms at levels well below most international and national guidelines. Effects inc...lude increased cancer risk, cellular stress, increase in harmful free radicals, genetic damages, structural and functional changes of the reproductive system, learning and memory deficits, neurological disorders, and negative impacts on general well-being in humans. Damage goes well beyond the human race, as there is growing evidence of harmful effects to both plant and animal life. The scientists who signed this appeal arguably constitute the majority of experts on the effects of nonionizing radiation. They have published more than 2,000 papers and letters on EMF in professional journals...." https://blogs.scientificamerican.com//we-have-no-reason-t/