National Centre for Neuroimmunology and Emerging Diseases in Gold Coast, Queensland | College & University

National Centre for Neuroimmunology and Emerging Diseases

Locality: Gold Coast, Queensland

Phone: +61 7 5678 9283

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25.01.2022 CHRONIC FATIGUE SYNDROME: ITS REAL + ITS DEBILITATING Its more than just being tired. Its got nothing to do with being lazy or making things up or bein...g a hypochondriac. Life with Chronic Fatigue Syndrome is full of stigma and frustration. So what is it like? Nelly Thomas, comedian and author, is a mother to a young girl with Chronic Fatigue Syndrome and Professor Sonya Marshall-Gradisnik, Griffith University, is researching Chronic Fatigue Syndrome - they both spoke with Kia Handley.

25.01.2022 Dear Supporters, To ensure clarity and transparency, NCNED has not extended any invitation to Emerge. Thank you to all who unreservedly support our team. We have wonderful data coming out in the coming months.... Best wishes NCNED

23.01.2022 / () - NCNED would like to hear from ME/CFS patients who are currently taking LDN. We are expanding our research sites to Sydney and Melbourne. If you have not already contacted NCNED regarding this research or filled in our online questionnaire, please contact us on (07) 56789283 or email [email protected]

22.01.2022 We are recruiting for current and upcoming CFS/ME studies we require both healthy volunteers as well as CFS/ME sufferers aged between 18-60 years old living in QLD. If you are interested in participating, could you please email [email protected] or call (07) 56789283 for further information. https://prodsurvey.rcs.griffith.edu.au/pr/index.php/275725

21.01.2022 Thank you to all of the participants who have completed our Diet and Gastrointestinal Surveys. We are still looking for more participants for this study - both ME/CFS participants and healthy volunteers. The study is open to Australian residents aged 18-60 years old, and will involve the completion of two online surveys. If you are interested in participating, please contact NCNED on (07) 56789283 or email [email protected] and we can sen...d you a questionnaire to fill in to determine your eligibility. Best wishes, NCNED

21.01.2022 Co-Director of NCNED, Professor Donald Staines, recently presented at the 14th Invest in ME Research International ME Conference in London on the 31st of May. Professor Staines presentation was titled "Transient Receptor Potential Ion Channels in the Aetiology and Pathomechanism of CFS/ME".

21.01.2022 , () , () , / Introducing Franziska Möckl from Professor Andreas Guses Laboratory, University Clinic Eppendorf (UKE) in Hamburg, who is undertaking a collaborative research project with NCNED. Franziska has nearly completed her very important research at NCNED where she has been undertaking research into the role... of a specific pharmacological agent for improvement in immune cell function. This data will be submitted for a publication by mid July. NCNED would sincerely like to thank our supporters, the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.

21.01.2022 On 18th July NCNED researchers Cassandra Balinas and Stanley du Preez attended the 19th International Congress of Mucosal Immunology Conference in South Bank, Brisbane. This conference exclusively focused on the interface between the immune system and the environment at mucosal surfaces. Both researchers presented posters entailing the novel identification and characterisation of TRPs from ME/CFS patients. Improving the functionality of these channels following drug modulation is currently being undertaken at NCNED.

21.01.2022 NCNED: Important Publication The NCNED team has just published an important paper titled A systematic review of cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID). Matthew Corbitt, Natalie Eaton-Fitch, Donald Staines, Helene Cabanas and Sonya Marshall-Gradisnik. To view the article, please use the following link: https://protect-au.mimecast.com/s/nKM7C5QZJlI1qRNrCyQaOc The results showed that cytokines do no...t exhibit a conclusive role in CFS/ME/ SIDS and thus do not serve as reliable biomarkers. Our research was based on a review of 16,702 publications of which 14 studies met acceptable scientific standards for analysis. Quality assessment was undertaken on study design, methodology and level of evidence. Ten of the studies measured serum cytokines, and four measured cytokines in other physiological fluids.

20.01.2022 : - We are inviting patients formally diagnosed with ME/CFS and healthy individuals to participate in an upcoming investigation to continue NCNED world class research in the area of calcium receptors, signalling and pharmaceutical intervention. NCNED will be further expanding our research in VICTORIA. ... NCNED collaborates with The Royal Melbourne Hospital for the collection of ME/CFS patient samples and is expanding to include the Australian Rickettsial Reference Laboratory, World Health Organisation (WHO) Reference Laboratory, Geelong. Participants will be asked to complete an online medical history questionnaire and to donate up to 85ml of blood. For their time, participants will receive a $5 Coles voucher and enter the draw to win a $100, $200 or $500 Coles voucher drawn half-yearly. Please contact us by email at [email protected] or call (07) 5678 9283 for further information. Best wishes Sonya, Don and the NCNED Team

19.01.2022 NCNED is delighted to introduce Ms Kay Schwarz (Acting Office Manager) who will be carrying out the duties of Ms Vivienne Hughes whilst she is on leave for an extended period. Kay brings to the team many years of experience in a supporting role and is looking forward to using her skills and knowledge to the benefit of both the Centre and our valued ME/CFS patients.

19.01.2022 / The ME/CFS Advisory Committee Report was finalised and submitted to the NHMRC Chief Executive Officer. Professor Sonya Marshall-Gradisnik was a member of this ME/CFS Advisory Committee. This report advises the NHMRC CEO on the current needs for research and clinical guidance for ME/CFS in Australia. The report can be found at: https://www.nhmrc.gov.au//mecfs-advisory-committee-report-

17.01.2022 NCNED is currently looking for individuals who have been clinically diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), as well as healthy volunteers, to participate in a research project investigating gastrointestinal symptoms and diet associated with ME/CFS. This study is open to Australian residents aged 18-60 years old, and will involve the completion of two online surveys. If you are interested in participating, ...please contact NCNED on (07) 56789283 or email [email protected] and we can send you a questionnaire to fill in to determine your eligibility. We would like to thank everyone for their support as without your generosity our research would not be possible. Best wishes, NCNED

16.01.2022 NCNED is pleased to expand on previous research findings as non-scientists may struggle with this information. Patch clamp is the gold... standard technique for ion channel research. NCNED is the first, and at this stage only, CFS/ME research group world-wide to undertake this challenging work on natural killer (NK) cellsan extraordinary achievement. If you are wondering about sample sizes, sample size is largely irrelevant in patch clamp research. Being a gold standard technique a study size of 2 (1 patient: 1 healthy control) is insightful and compelling. A study of 6 patients and 6 age and sexed matched controls is far in excess of acceptable scientific methodology. NCNED has now reproduced and published these important results twice with another publication in this area being finalised in the coming weeks. Other groups have not mastered these techniques yet, although we encourage them to do so. NCNED has simultaneously published the scientific techniques associated with these results and will be pleased to share these methodological techniques with any reputable scientific research group engaged in bona fide CFS/ME research. All NCNED research papers undergo a rigorous peer review process by appropriately skilled scientists who have expertise in this area prior to acceptance and publication. Ill informed commentary is regrettable as it demonstrates we have some way to go to overcome poor understanding of appropriate scientific methodologies in some sections of the CFS/ME social media arena. The finding of TRP associated pathology is an exciting development in CFS/ME research and the patch-clamp technique enables pharmacotherapeutics to be tested in the laboratory to discover suitable drugs for patients. We are making great progress in this area. Thank you to all our wonderful supporters and we will try to explain it all as we move forward. Best wishes Sonya, Don and the NCNED team who are working for the CFS/ME patients to make a difference.

15.01.2022 : The NCNED team has just published a titled ‘A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome’. Natalie Eaton-Fitch, Stanley du Preez, Hélène Cabanas, Donald Staines & Sonya Marshall-Gradisnik. NCNED is committed to publishing novel high quality and rigorous research papers in the field of ME/CFS. NCNED also endeavours to robustly evaluate the research li...terature (also known as systematic reviews) in ME/CFS to assist and inform researchers and patients. NCNED has previously reported in a number of systematic reviews there is currently no conclusive evidence that suggests cytokines and microbiome serve as unique biomarkers for development of ME/CFS. Additionally, our reviews also reported that supplements do not sufficiently assist in the management of ME/CFS. , by Eaton-Fitch and NCNED researchers now reports impaired / . To view the article, please click on the following link: https://systematicreviewsjournal.biomedcentral.com//s13643 Our research was based on a review of 523 publications of which 17 studies met . Quality assessment was undertaken on study design, methodology and level of evidence. NCNED is always thankful to every participant in our research. We also would like to thank the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS. Best wishes Sonya, Don and the NCNED team

14.01.2022 - ! Our Economic Impact Survey will be closing at the end of the week.... If you would like to contribute to this important research, please complete the survey by clicking on the link below: https://prodsurvey.rcs.griffith.edu.au//in/register/index This Survey is paired with the NCNED Research Registry Survey which can be completed or finalised here: https://prodsurvey.rcs.griffith.edu.au/pr/index.php/275725 Thank you to all of our supporters.

14.01.2022 Michael Matula is a research student who has recently joined NCNED. Michael is a Clinical Physiologist in Respiratory and Sleep Medicine. His research project will involve reviewing the literature on the link between objective measures of sleep quality (such as sleep efficiency and staging demonstrated on the hypnogram of the EEG) and symptoms experienced by patients. A case series of patients with diagnosed CFS/ME assessed through various sleep centres will then be compiled,... the data analysed and their PSG findings compared with their documented symptoms from a thorough quality of life questionnaire. It is hoped that by understanding the possible link between objective sleep disruption and symptoms affecting quality of life, this can give insight on ways to improve sleep architecture and the effect this would have on the symptoms experienced by these patients. See more

13.01.2022 , (), () /. Dr Helene Cabanas, Ms Cassandra Balinas and Mrs Natalie Eaton-Fitch will be attending and presenting important data from NCNED. The data presented at the FASEB Conference will outline a second ME/CFS cohort investigated at NCNED which has TRPM3 dysfunction. Importantly this new study ...re-validates previous findings reporting this dysfunction of TRPM3, a calcium channel receptor, in a separate ME/CFS cohort. This new study also reported even using another TRPM3 activator, Nifedipine, did not activate this receptor for calcium entry. NCNED would like to thank all the patients who participated in this research and our supporters. Thank you to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.

13.01.2022 , NCNED research team member, Dr Helene Cabanas, attended and presented her research at the prestigious international EMBO symposium held in Bangalore, India from the 26th to the 29th of January 2020. The focus of this meeting was on the most recent developments in calcium signalling and their impact on health and disease. Dr Cabanas presented a research poster that identified for the first time the calcium-permeable nonselecti...ve cation channel, TRPM3, as a novel and attractive therapeutic target for the treatment of ME/CFS. She reported impaired TRPM3 ion channel function in immune cells from three different cohorts of ME/CFS patients using the gold standard of patch clamp technique. She also presented novel data describing restoration of TRPM3 ion channel function after in vitro treatment with Naltrexone, suggesting the potential use of this drug as a therapeutic intervention for ME/CFS. NCNEDs world leading research showing ion channels and calcium signalling are implicated in ME/CFS highlights the role of numerous TRPs in the pathology of ME/CFS. NCNED continue to expand TRP and calcium investigations in ME/CFS. , , , , , , , , , , , // , / / .

13.01.2022 , () , () , / Introducing Franziska Mckl from Professor Andreas Guses Laboratory, University Clinic Eppendorf (UKE) in Hamburg, who is undertaking a collaborative research project with NCNED. Franziska has nearly completed her very important research at NCNED where she has been undertaking research into the role... of a specific pharmacological agent for improvement in immune cell function. This data will be submitted for a publication by mid July. NCNED would sincerely like to thank our supporters, the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.

13.01.2022 The NCNED team are pleased to announce the publication of the paper, Health-related quality of life in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Australian cross-sectional study - Natalie Eaton-Fitch, Samantha Johnston, Pawel Zalewski, Don Staines and Sonya Marshall-Gradisnik. This research represents the largest study to assess quality of life in Australians diagnosed with ME/CFS. NCNED report for the first time the significant impact this dis...ease has on quality of life. Our researchers analysed 480 survey responses submitted by ME/CFS patients. Eaton-Fitch reports significantly low quality of life scores due to cognitive symptoms, sleep and sensory disturbances, and autonomic and immune dysfunction. This publication provides evidence of the disabling effects of ME/CFS and the impaired quality of life which hopes to motivate the Australian public health community to renew public health policies and increase focus on patient care. NCNED is thankful to the patients who participate in our research and continue to support the centre. We would also like to thank the Stafford Fox Medical Research Foundation, the Mason Foundation, Mr Douglas Stutt, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and ME/CFS and Lyme Association of WA Inc. To view this article, please click on the following link: https://link.springer.com/artic/10.1007/s11136-019-02411-6 Best wishes, Sonya, Don and the NCNED Team

12.01.2022 : / / . NCNED is the peak research centre nationally and is internationally recognised for its world-leading research on the identification of the pathology, developing a screening test and pharmacotherapeutic intervention for ME/CFS. ... NCNED researchers were the first in the world to develop the gold-standard in experimental research known as patch clamp technique in immune cells to measure TRP receptor function. Cabanas, H, Muraki, K, Staines, D and Marshall-Gradisnik, S published these important findings in Frontiers Immunology. The full publication will be released in the coming weeks, however, the abstract is provided below: https://www.frontiersin.org//10./fimmu.2019.02545/abstract In this new pivotal research publication, Dr Cabanas and NCNED researchers report Naltrexone (NTX) restored TRPM3 activity in Natural Killer (NK) cells from ME/CFS patients. NCNED researchers use NK cells as a model for assessing TRPM3 and other TRP function and which reflects physiological activity in all body tissues expressing these ion channels. This groundbreaking discovery used the advanced and gold-standard electrophysiology technique known as patch clamp in immune cells to / . Importantly, NCNED researchers used , a known opioid antagonist used by ME/CFS patients, to in immune cells from ME/CFS patients. This world first discovery suggests - /. Thank you to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.

12.01.2022 Dr Leighton Barnden and NCNED Researchers have just published a novel significant paper. The research paper published in Neuroimage: Clinical reported / . () . ... , , , , /. : https://www.sciencedirect.com//artic/pii/S2213158219303924 Ion channels are located in this region and others of the brain. , , , , , , , , , , , // , / /.

10.01.2022 , From January 26-29th, Ms Cassandra Balinas attended and presented her research and NCNED data at the prestigious EMBO Symposium recently held in Bangalore, India. This prestigious conference focused on calcium signalling and molecular mechanisms in health and disease. Cassandra presented NCNED research data that identified differential surface expression of TRPM2 and TRPM3 ion channels on NK cells. She also presented novel dat...a of impaired surface expression from TRPM2 and TRPM3 that is implicated in the dysregulated NK cell cytotoxicity in ME/CFS patients. NCNED world leading ion channels and calcium research in ME/CFS highlights numerous TRPs are involved in the pathology of ME/CFS. NCNED continue to expand TRP and calcium investigations in ME/CFS. , , , , , , , , , , , // , / / .

10.01.2022 . Thank you to all of the donors and participants, especially to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association ...QLD Inc, the ACT ME/CFS Society and ME/CFS and Lyme Association of WA Inc. We will be back in early January 2020 as we continue our exciting ME/CFS research. Best wishes, Sonya, Don and the NCNED Team

09.01.2022 Thank you to the Henty community. Professor Sonya Marshall-Gradisnik and Dr Helene Cabanas sincerely thank everyone who attended the NCNED Research Update at the Henty Community Club on Friday 25 October. We love visiting you. Best wishes, Sonya, Don and the NCNED Team

09.01.2022 , / , : / Ms Cassandra Balinas and NCNED researchers have just published a novel significant paper reporting another TRP channel involved in ME/CFS pathology. The research paper published in the Journal of Translational Medicine reported / . ... Ms Balinas also found the additional protein, CD38, that acts together with TRPM2 to cause NK lysis was not changed in expression in ME/CFS patients compared to healthy participants. , / . : https://translational-medicine.biomedcentral.com//s12967-0 NCNED world leading ion channels and calcium research in ME/CFS highlights numerous TRPs are involved in the pathology of ME/CFS. NCNED continue to expand TRP and calcium investigations in ME/CFS. , , , , , , , , , , , // , / / .

09.01.2022 CHRONIC FATIGUE SYNDROME: IT'S REAL + IT'S DEBILITATING It's more than just being tired. It's got nothing to do with being lazy or making things up or bein...g a hypochondriac. Life with Chronic Fatigue Syndrome is full of stigma and frustration. So what is it like? Nelly Thomas, comedian and author, is a mother to a young girl with Chronic Fatigue Syndrome and Professor Sonya Marshall-Gradisnik, Griffith University, is researching Chronic Fatigue Syndrome - they both spoke with Kia Handley.

08.01.2022 / () NCNED would like to hear from ME/CFS patients who are currently taking LDN. If you are a ME/CFS patient taking LDN and would consider participating in a research program please contact NCNED. For further information please email [email protected] or call (07) 56789283.

07.01.2022 NCNED welcomes Kiran Thapaliya who will be working as a Research Fellow in the area of Neuroimaging with NCNED researchers. Kirans expertise is the area of modelling MR signals to study tissue microstructure in the human brain using multi-echo gradient echo at 7 Tesla. His expertise is on myelin imaging, signal modelling, magnetic susceptibility and quantitative susceptibility mapping. Best wishes... Sonya, Don and the NCNED team See more

07.01.2022 Cassandra Balinas and the NCNED researchers published an important paper today. This study for the first time identified TRPM2 on NK cells in healthy participants. :... 1. First study to develop an in vitro methodology to identify and characterise TRPM2 and CD38 surface expression on NK subsets from healthy control participants. . . 3. NCNED is now assessing TRPM2 from CFS/ME patients and trialling other drugs to target TRP channels for benefiting CFS/ME patients. This significant paper is a pioneering paper which has enabled NCNED to undertake further TRPM2 investigations in CFS/ME patients. This latter focus is nearly completed too and is also being submitted this week! Stay tuned for the second paper in the coming months. https://bmcimmunol.biomedcentral.com//10/s12865-019-0293-0 Best wishes Sonya, Don and the NCNED team

07.01.2022 : We are inviting patients formally diagnosed with ME/CFS and healthy individuals to participate in an upcoming investigation to continue NCNED world class research in the area of calcium receptors, signalling and pharmaceutical intervention. NCNED will be further expanding our research in VICTORIA in February and March 2020.... NCNED collaborates with The Royal Melbourne Hospital for the collection of ME/CFS patient samples and is expanding to include the Australian Rickettsial Reference Laboratory, World Health Organisation (WHO) Reference Laboratory, Geelong. Participants will be asked to complete an online medical history questionnaire and to donate up to 85ml of blood. For their time, participants will receive a $5 Coles voucher and enter the draw to win a $50, $75 or $100 Coles voucher drawn half-yearly. Please contact us by email at [email protected] or call (07) 5678 9283 for further information. Best wishes Sonya, Don and the NCNED Team

07.01.2022 - ! Our Economic Impact Survey will be closing at the end of May 2019.... Understanding the economic impacts of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is important in informing public health decision making and improving illness management. If you would like to contribute to the economic impact research or make sure that your survey is completed and submitted you can access the survey here: https://prodsurvey.rcs.griffith.edu.au//in/register/index The Economic Impact Survey is paired with the NCNED Research Registry Survey - which can be completed or finalised here: https://prodsurvey.rcs.griffith.edu.au/pr/index.php/275725 Thank you to all our supporters and participants - your continued support is critical to NCNEDs research and is greatly appreciated.

06.01.2022 : NCNED research team member, Dr Helene Cabanas, attended and presented data from NCNED at the prestigious international Gordon Research Conference held in Mount Snow, VT, USA from the 3rd to the 9th of August, 2019. The focus of this meeting was on the most recent progress in new technologies in understanding the dynamics and physiology of organellar ion channels and transporters. Understanding the role of organ...ellar ion channels and transporters will help elucidating new prognostic markers and/ or therapeutic targets for ME/CFS. NCNED research data was received extremely well. Best wishes, NCNED Team

06.01.2022 / . Dr Leighton Barnden, NCNED, recently presented MRI data from NCNED at the 2019 Organization for Human Brain Mapping Conference titled "Connectivity within the brainstem is impaired in chronic fatigue syndrome". Leightons research reported significant differences were found between ME/CFS and HC for connectivity within the brainstem. Impaired brainstem connectivity can expla...in reported autonomic and compensatory structural changes in CFS as previously reported by NCNED (Barnden, 2015, 2016), and may also explain the impaired cognitive performance, sleep quality and pain of ME/CFS. NCNED would like to thank all the patients who participated in this research and our supporters. Thank you to the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS.

05.01.2022 Professor Sonya Marshall-Gradisnik and Professor Donald Staines will be presenting a ME/CFS Seminar on 12 September, 2019 from 11am to 2pm at the ME/CFS and Lyme Association of WA in Perth. They will be discussing advances in discovering the pathology of ME/CFS by the NCNED team. Bookings are essential - for tickets and event information please click on the following link: http://bit.ly/ncnedperth19 Further information can also be found at: https://www.facebook.com/events/405412543443553/

05.01.2022 / We are recruiting for upcoming ME/CFS studies to continue NCNED world class research in the area of calcium receptors, signalling and pharmaceutical intervention. We require both healthy volunteers as well as ME/CFS sufferers aged between 18-60 years old, non-smoking and not currently taking medication. Participants will be asked to complete an online medical history questionnaire and to donate up to 85ml of bloo...d. For their time, participants will receive a $5 Coles voucher and enter the draw to win a $50, $75 or $100 Coles voucher drawn half-yearly. If you are interested in participating, could you please email [email protected] or call (07) 56789283 for further information. https://prodsurvey.rcs.griffith.edu.au/pr/index.php/275725

05.01.2022 : The NCNED team has just published a titled A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome. Natalie Eaton-Fitch, Stanley du Preez, Hlne Cabanas, Donald Staines & Sonya Marshall-Gradisnik. NCNED is committed to publishing novel high quality and rigorous research papers in the field of ME/CFS. NCNED also endeavours to robustly evaluate the research li...terature (also known as systematic reviews) in ME/CFS to assist and inform researchers and patients. NCNED has previously reported in a number of systematic reviews there is currently no conclusive evidence that suggests cytokines and microbiome serve as unique biomarkers for development of ME/CFS. Additionally, our reviews also reported that supplements do not sufficiently assist in the management of ME/CFS. , by Eaton-Fitch and NCNED researchers now reports impaired / . To view the article, please click on the following link: https://systematicreviewsjournal.biomedcentral.com//s13643 Our research was based on a review of 523 publications of which 17 studies met . Quality assessment was undertaken on study design, methodology and level of evidence. NCNED is always thankful to every participant in our research. We also would like to thank the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Mason Foundation, the McCusker Charitable Foundation, Mr Adrian Flack, Mr and Mrs Ian and Talei Stewart, the Alison Hunter Memorial Foundation, the Buxton Foundation, the Henty Community, the Blake Beckett Foundation, Change for ME Charity, QLD ME/CFS/FM Support Association QLD Inc, the ACT ME/CFS Society and WA ME/CFS. Best wishes Sonya, Don and the NCNED team