Curtin Health Innovation Research Institute in Bentley, Western Australia | Educational research centre

Curtin Health Innovation Research Institute

Locality: Bentley, Western Australia

Phone: +61 8 9266 1649

Address: Curtin University Bentley, WA, Australia

Website: https://chiri.curtin.edu.au/

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• Non-profit organisation
• Educational research centre
• Medical research centre

25.01.2022 There’s hope for new developments in the treatment of Meniere’s disease and other inner ear disorders, with USA-based non-profit Cures Within Reach providing $89,000 in funding to Curtin University for research led by Dr Daniel Brown and Dr Hani Al-Salami from CHIRI’s Biotechnology and Drug Development Research Lab and Curtin’s School of Pharmacy and Biomedical Sciences. Combining cutting-edge bio-nano technologies led by Hani’s team, with Daniel’s expertise in understanding the mechanisms underlying Meniere’s disease, the pair are working together to develop new drug formulation systems to more effectively treat substantive inflammation and fluid-related disorders of the inner ear. Read more on our blog https://buff.ly/3enBqnn

24.01.2022 We are so excited about the arrival of @CHIRI_curtin's new ZEISS Microscopy slide scanner we made a video about it. Check out our Senior Tech Officer Michael Nesbit putting the technology through its paces below. The installation of the slide scanner marks the first step towards a $1.2m super-rapid speed confocal microscopy suite in our shared use facilities, with funding from Australian Research Council's LIEF 2020 scheme. Our special thanks to the ARC and the 63 leading r...esearchers from both in and outside CHIRI who supported the funding application and helped secure these cutting-edge technologies for the benefit of the WA research community. Read more on our blog: https://buff.ly/31IvIs7

23.01.2022 The brain is a complex maze but advances in neuroscience have helped researchers learn more about it in the past two decades than ever before. Researchers at CHIRI are hopeful that better outcomes for patients with degenerative brain diseases such as Multiple sclerosis, Parkinson’s disease and Alzheimer’s disease are getting closer, and we need your help to get there. We are recruiting study participants to help us explore a promising research lead, assessing how people res...pond to meals containing commonly consumed dietary oils and the effectiveness of these oils to influence blood metabolites that positively regulate capillary vessel function. Capillaries are microscopic blood vessels that are critical for brain function and mental health and keep the brain isolated and protected from infectious diseases. CHIRI researchers have discovered that brain capillaries become increasingly leaky with age and that poor dietary behaviour accelerates this process. Capillaries that persistently leak cause silent inflammation, which can increase the risk of developing degenerative brain diseases. However, dietary behaviour can also strengthen brain capillaries and reduce disease risk, which is the part researchers are keen to investigate further. If selected for the study, you will receive a range of results (glucose, cholesterol and a blood lipid profile) that are relevant to heart health. You would also receive a voucher for your time commitment upon the study’s completion. Want to know more about how we can put our heads together to find a way around brain disease? Read more about the study or register your interest to participate on Eventbrite https://buff.ly/2XnwpVC or phone 0404 411 589.

23.01.2022 Remember this special pup Paddy? He's been reunited with CHIRI researcher Associate Professor Delia Nelson for this 9 News Adelaide report. To recap from our previous post, Paddy is part of a dog cancer treatment trial Delia is leading at Curtin University that’s raising hopes for a more effective immunotherapy treatment to soft tissue sarcomas, that can also occur in humans. Paddy’s tumour completely disappeared following his treatment in the trial and he is among the 30% ...of dogs treated in the first group who showed complete remission from their cancers without any side effects from the Selvax therapy being trialled. Watch the video to see how Paddy is going.

22.01.2022 Celebrating the arrival of 2021 and all our amazing followers whose support make each year extra special. On behalf of all of us at the Curtin Health Innovation Research Institute, best wishes and thank you!

22.01.2022 Curtin University and CHIRI’s Associate Professor Nina Tirnitz-Parker and Director of the Harry Perkins Institute of Medical Research, The University of Western Australia's Professor Peter Leedman (pictured right), will co-lead a collaborative team of researchers testing new treatments for primary liver cancer at a new $10.8 million world-class research centre for Perth. Announced this week, the centre will be established with a $5 million Cancer Research Trust grant and $5.8... million from Minderoo Foundation, Curtin University, UWA, Harry Perkins Institute of Medical Research, the WA Government and charitable organisations. Carrying out the research will be the Western Australian Liver Cancer Collaborative, a team of more than 50 researchers from UWA, the Harry Perkins Institute of Medical Research and Curtin-CHIRI. The team will apply the latest techniques to analyse patient tumours and test new treatments for malignant cancer starting in the liver, which is responsible for the third-most cancer related deaths worldwide. The team includes Nina and her CHIRI colleagues Associate Professor Pieter Eichhorn, Professor Marco Falasca and Dr Rodrigo Carlessi (pictured left), all from Curtin’s School of Pharmacy and Biomedical Sciences. Also involved in the research will be Perth’s three main teaching hospitals as well as interstate and international collaborators. Among the team’s aims are establishing and profiling a repository of organoids representing different tumour subtypes to screen for possible treatment choices without side effects to the patient; and developing a large resource of approximately 500 liver cancer samples over five years from across Australia. Nina said the team was incredibly grateful to the Cancer Research Trust for its $5 million grant matched by a further $5.8 million from generous donations. Minderoo Foundation is providing $2.5 million, Curtin University $1 million, $500,000 is being contributed by each of UWA, the Harry Perkins Institute of Medical Research, the WA Health Department and the Sir Charles Gairdner Hospital Foundation Charlies Foundation for Research. The McCusker Charitable Foundation is contributing $300,000. Such a significant investment in liver cancer research will enable us to develop a world-class bio-bank and collect extensive data that will be available to researchers and medical specialists around the world, Nina said. Most importantly, the Centre will make a difference to the treatment of liver cancer and contribute to greater international understanding of the disease. You can read more about funding for the centre and its research in the Curtin University media release: https://buff.ly/2CfCz2G

19.01.2022 We are excited to share that a Curtin University research project led by CHIRI’s Associate Professor Pritinder Kaur, from the School of Pharmacy and Biomedical Sciences, will receive $737,689 in funding to develop a 3D printing-based system to revolutionise the treatment of skin trauma. Supported by a Australian Government Department of Health Medical Research Future Fund (MRFF) Stem Cell Therapies 2020 grant, the research has the potential to speed up the healing process, re...duce surgical and hospitalisation times and improve skin function for patients with skin wounds and scars. Head of CHIRI’s Epithelial Stem Cell Biology Group, Pritinder and her team will develop and optimise a clinical prototype 3D bio-printing platform that uses stem cells to print skin tissue directly onto model wounds, as a precursor to skin repair in humans. Pritinder will collaborate with seven key Australian investigators on the project, including WA burns surgeon Professor Fiona Wood and bio-printing and bioengineering expert Professor Gordon Wallace from the UOW: University of Wollongong, Australia. CHIRI Director Professor John Mamo said, This research bodes well for realising new treatments for persistent or slow-healing wounds that commonly occur in older-aged Australians with chronic diseases such as diabetes. I am thrilled that this MRFF funding will enable Pritinder and her team to progress this important research, which has the potential to greatly improve outcomes for patients with skin injuries of all ages, including as a result of age and disease. You can read more about the funded research project here https://buff.ly/2zUC1OI

19.01.2022 A CHIRI-led research collaboration Curtin University has found a new link between sub-concussion and motor dysfunction in a study designed to replicate the impact suffered by some sport players. Just published in the journal Frontiers in Neurology, the research is led by CHIRI’s Ryu Takechi, from Curtin’s School of Public Health, whose team worked in collaboration with Melinda Fitzgerald’s team from the Perron Institute for Neurological and Translational Science/Sarich Neuro...science Research Institute and CHIRI, and several other Curtin researchers. The multi-disciplinary team has developed a novel model to understand more about the potential effects of low-grade cranial impact on neuromotor function. The study found that only the repeated modest sub-concussion over a period of 12 weeks showed neuromotor deficits, while short-term periods such as two weeks had no effect. Sport is a way of life for Australia, however little is known about potential risks associated with repeated head impact later in life. The findings raise awareness of the need to consider health risks associated with long-term exposure of even modest but repeated head impact situations. More about the research, including a link to the full paper, here: https://buff.ly/2BN2i2a

19.01.2022 Looking for a postdoctoral fellow position in cancer research? Look no further, details here: https://buff.ly/3jvWnAq. Applications close on 1 May 2021.

18.01.2022 Thanks for your support this year! On behalf of all of us at Curtin-CHIRI, we wish you and your family all the very best for the festive season. CHIRI has now entered a limited service period for the holidays, returning on Monday 4 January. Have a great break and we look forward to sharing more of our research and achievements with you in 2021.

18.01.2022 We’re pleased to be part of the new $10.8 million Western Australian Liver Cancer Centre with Harry Perkins Institute of Medical Research and The University of Western Australia, aiming to transform how liver cancer is treated. Read full story: http://curtin.edu/3y61a5

15.01.2022 Hearing loss sufferers worldwide will reap the rewards of three globally recognised research brands with Ear Science Institute Australia (ESIA), Curtin University and William Demant Foundation joining forces to establish a ‘Hearing Sciences’ joint venture. View the full story here: https://buff.ly/2MOAal9.

14.01.2022 Looking forward to seeing CHIRI researcher and Australian and New Zealand Society for Immunology - ASI Honorary Secretary Connie Jackaman host this online event. RSVPs open!

13.01.2022 The search for immunology-based insights into the muscle disease dysferlinopathy is on, with the JAIN Foundation funding research by Curtin-CHIRI's Connie Jackaman in collaboration with Hannah Radley (also Curtin-CHIRI) and Miranda Grounds (UWA) to the tune of $159,089. The team will use the funding to systematically investigate changes across various immune cells in dysferlinopathy during ageing. One example of this is looking for structural changes in tissues involved in i...mmune function, such as the spleen (see images in this post). Find out more on our blog: https://buff.ly/3pwoWPw

12.01.2022 Just as the lotus flower is a symbol of long life and health, the inaugural Lions-Lotus PhD Scholarship recipient Nathan Main is hoping to improve both the lives and health of chronic liver disease patients through his research project at CHIRI. Supported by the Lion’s Cancer Institute, Nathan’s PhD research focuses on decoding the language cells use to communicate, which may contribute to cancer initiation. If found to be significant to liver disease, these cells may be tar...geted with therapeutics to block liver cancer formation. Nathan’s highly anticipated arrival at CHIRI is timely in more ways than one. Recent research findings by the Liver Disease and Regeneration Group at Curtin-CHIRI has identified a ‘goldmine’ of genetic markers and protein receptor-ligand pairs that are possible contributors and predictors of liver cancer, and provide prime candidates for Nathan’s research. Nathan’s appointment also coincides with the announcement of a $10.8 million boost for primary liver cancer research in WA. Read more about the exciting times ahead for Nathan and his liver cancer research on our blog: https://buff.ly/3m4tU4u

12.01.2022 What’s got this dog Paddy, his family and vets looking so happy? He’s a patient in a Curtin University dog cancer treatment trial led by CHIRI’s Associate Professor Delia Nelson, with long-time involvement from Research Associate Stephen Proksch (both from Curtin's School of Pharmacy and Biomedical Sciences) that’s showing some promising results for dogs and humans. Curtin University and West Australian cancer immunology company Selvax Pty Ltd is working in cooperation with ...Perth Veterinary Specialists to conduct the trial, which has resulted in significant cure rates of dogs with soft tissue sarcomas in the first group of ten dogs tested. We are pleased to report that Paddy is one of them! Following treatment in the trial, Paddy’s tumour has completely disappeared. Delia says the interim results of the trial strongly suggest that, with continued development, this treatment could have potential for the treatment of sarcomas in humans. You can read more about CHIRI’s involvement in the trial, the results so far, and what they may mean for human cancer patients on our blog: https://buff.ly/2M8SpOa

11.01.2022 As Western Australia’s research community gathered for the inaugural Annual General Meeting of the Perth Protein Group in Albany this month, several of the Curtin Health Innovation Research Institute (CHIRI) team were on hand to contribute their expertise and to celebrate an award-winning presentation by one of our students. CHIRI Masters student Aleshanee Paxman delivered the Best Student Talk of the three-day event. Aleshanee’s presentation was on cell biology and cancer research she’s undertaking at CHIRI, as part of her Masters studies within Curtin University’s School of Pharmacy and Biomedical Sciences. Keep reading on our blog: buff.ly/2RTO1Fz

07.01.2022 With the help of a $10K Early Career Researcher grant from AINSE Ltd., CHIRI and Curtin University researcher Dr Gae Ellison is hoping to bring new information about diabetes to light by using synchrotron technology at ANSTO's Australian Synchrotron Facility to map biometals in the pancreas. Read more about Gae and the research on our blog: https://buff.ly/34aGRTd

06.01.2022 A big and tall congratulations to CHIRI researcher Associate Professor Nina Tirnitz-Parker, who has received a 2020 Young Tall Poppy Science Award from the Australian Institute of Policy and Science (AIPS). Nina, from Curtin University's School of Pharmacy and Biomedical Sciences, is a liver cancer researcher chosen for the award for both her achievements in scientific research and getting word of her research out to the public. Nina will formally receive her award at a cer...emony later in 2020, and over the next year will be helping the AIPS build more publicly engaged scientific leaders in Australia by promoting interest in science at schools, and an understanding and appreciation of science in the broader community. You can find out more about Nina here https://buff.ly/3j9JhHx, and about the Tall Poppy Campaign here https://buff.ly/34znnJF Tall Poppy Campaign Curtin University

06.01.2022 With the support of a three-year Postdoctoral Fellowship from Cancer Council Western Australia, CHIRI researcher Dr Rodrigo Carlessi will continue to work on world-first experimental design aimed at detecting liver cancer before it appears, with the goal of informing the first screening program for the disease in Australia. Read more on our blog: https://buff.ly/3iUxuOl

03.01.2022 We’re predicting great things from this funding news $240,000 awarded by the Western Australian Cancer Single Cell Consortium for liver cancer research led by CHIRI researcher Dr Rodrigo Carlessi, with our Associate Professor Nina Tirnitz-Parker, to investigate how damaged liver cells can predict liver cancer prior to its development. Rodrigo and Nina, from Curtin University's School of Pharmacy and Biomedical Sciences, are part of a team of national experts working to deci...pher liver cancer at the single cell level, with a focus on the predicting role of the gene expression repertoire in the disease. Liver cancer being particularly common among older patients highlights the potential for disease intervention early on and the significance of the research to CHIRI’s focus on age-related diseases and disorders. Read more about the team’s innovative approach to predicting liver cancer early on our blog https://buff.ly/2ZqvuE8

02.01.2022 Innovative by name and by nature: A team including Curtin-CHIRI researchers Hani Al-Salami, Armin Mooranian & Daniel Brown just crowned overall winners of the Curtin University 2020 Curtinnovation Awards for their development of a new gel formula treatment that helps improve outcomes for people with hearing loss. CHIRI's Josh Ravensdale was also recognised in the Science and Engineering category. Congratulations to all the winners, including our team and their collaborators.... You can read more about their projects here: http://bit.ly/3nKLmvX

01.01.2022 A multi-disciplinary research collaboration led by our Director Professor John Mamo will study a potential new treatment to slow cognitive loss in Alzheimer’s disease. Based on their findings from pre-clinical studies that in 2013 were awarded the prestigious National Health and Medical Research Council - NHMRC Marshall and Warren Award for innovation, the team has now been funded to test a promising drug in clinical trials. The research team is substantial and includes sign...ificant contributions from internationally-recognised discipline and opinion leaders. A $150,000 contribution was provided by MSWA in 2019 to help develop the clinical trial concept, which will now be fully supported through a $1.72 million neurological grant announced in the Australian Government Department of Health Medical Research Future Fund this week. Find out more in our blog https://buff.ly/3eE3Ud4 and the Curtin University media statement https://buff.ly/2BLUfCt.