Steve Holmes | Public figure

Steve Holmes

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22.01.2022 https://youtu.be/RYfmRTyl56w

22.01.2022 Paddock Ecom! Thanks to Chipotle, farmers’ markets are going virtual Chipotle is in the grits business now. The burrito giant just launched an ecommerce platform for 4 of its major farm partners. On top of the usual Chipotle fare -- meat, dairy, rice -- you can now snag a bag of grits or popcorn. ... Chipotle paid to set up the virtual storefronts, and it will continue to cover the hosting fees for 2 years, but all profits are going to the farmers. Why is Chipotle so ag-gressive about online produce sales? Disruptions to the supply chain mean its suppliers have plenty to offer but no place to sell. While some small farms do sell items straight to consumers -- think of those roadside apple stands -- they don’t usually have the resources for a slick online shopping system. The pandemic is goading farmers into ecommerce Over the last few months, companies like Steward and Agrellus have been trying to get farmers to try direct-to-consumer marketing. But Chipotle is the biggest player yet to throw its weight behind online farm stands. Ecommerce isn’t the only new sales method of the COVID-19 era. In China, some potato purveyors are live-streaming their sales. Prefer not to see a human when shopping for your breakfast? Try a contactless egg vending machine.

21.01.2022 What is TMB, Tumor Mutation Burden Attention Newly Diagnosed Patient and Caregivers, this is a term that you must know - https://immunobeginner.com/tumor-mutation-burden/

21.01.2022 Excerpt from an investment offer - This gives a great insight into current trends. This is not just about money - Invest in the identity authentication AI that took down 3 organized fraud gangs in 2019... Whoever said robots can’t fight crime has clearly never heard of TrustStamp (or Robocop). This new identity authentication system was created to combat the widespread issue of identity theft and financial breaches and boy, is it working. TrustStamp even just beat out hundreds of other companies to win a 2020 Blue Tulip Award for Finance, which identifies the most promising startups and innovations. What’s their secret sauce? Tokenized identity. TrustStamp’s patented tech creates individual tokenized identities from any biometric source. This allows institutions like banks and workplaces to authenticate your identity through facial recognition. In other words, nobody’s gonna be stealing your identity just because they have some of your personal info. And the market for this tech is huuuuuge: By 2023, biometrics will authenticate $2 trillion of in-store and mobile payments and generate $54B in revenue for the companies that handle it. TrustStamp aims to have annual recurring revenue between 0.25% and 0.75% of that market by 2024 -- that’s anywhere from $135-$405 million in ARR TrustStamp has already received strategic investment from Mastercard (after graduating from their Start Path accelerator program), but now they’re looking for more

21.01.2022 Facebook CEO Mark Zuckerberg says that Instagram will get a new dedicated shopping tab in the coming months Facebook really wants you to go from Like to Buy. On Tuesday, Mark Zuckerberg announced a set of new features aimed at making Instagram and Facebook true shopping destinations, by offering struggling brick-and-mortar shops new options to sell to customers online. If successful, the initiatives would make it easier for Instagram and Facebook users to discover and buy... products right from the apps. This could also boost Facebook’s business since it offers retailers of all sizes even more reasons to buy ads on the two giant social networking apps. The big new feature for online merchants is called Facebook Shops. These customizable online storefronts, which live on a Facebook page or Instagram profile, allow people to browse and purchase items without leaving the apps. Zuckerberg also said that in the coming months Instagram would be adding a dedicated shopping tab to the app’s main navigation bar, which would make it more obvious to Instagram users that they can do more than swipe and Like on the app. This is the biggest step that we’ve taken yet [in e-commerce], Zuckerberg said in an announcement livestreamed on Facebook on Tuesday afternoon.

20.01.2022 Which way are the new normal winds blowing - I think much will virtually vanish, and as Warren said so well - "When the tide goes out, we will soon see who is swimming naked" - I think this time, it will be more about spotting who still has togs on! WOODSTOCK FOR CAPITALISTS What happened when the Oracle of Omaha went virtual... Financial pros like to call Berkshire Hathaway’s annual shareholder meeting Woodstock for Capitalists -- and 2020’s version looked a lot like every other major festival that decided to forge ahead through the coronavirus pandemic. On Saturday, Warren Buffett, Berkshire’s billionaire CEO and the so-called Oracle of Omaha, held court remotely. He typically presents to an audience of thousands in Nebraska’s largest city -- last year’s bash brought in 40k+ people, and the event generates an estimated $21.3m for the city. Investor Woodstock 2020 looked VERY different For one thing, the virtual version of Buffett-mania devastated Omaha’s local businesses (in 2019, hotel revenue alone totaled $6.7m). Here are 5 other things we learned: 1 Buffett believes in America’s long-term economic prospects. We’re still a better country now than at any point in our history -- and we’ve been through worse before, Buffett said. His message: Never bet against America. 2 But we’re still waiting for his next big acquisition. Berkshire just reported a $49.7B loss for the 1st quarter. But at the same time, it’s stockpiling cash: $137B worth. The pandemic may present buying opportunities, but Bloomberg noted that Buffett is staying on the sidelines -- in contrast to his strategy during the 2008 financial crisis. 3 And Berkshire’s airline selloff is a sign of tough times. The conglomerate sold ~$6.5B of stock in April, including its entire stakes in United, American, Delta, and Southwest Airlines. The world changed for airlines, Buffett said. 4 The insurance industry will be the next battleground. Buffett predicted that we’ll see a flood of litigation in the coming months, from companies that go to war with their insurance companies over lost business due to the pandemic. 5 Buffett may be a billionaire, but he’s also a normal like the rest of us. It’s been 7 weeks since he’s had a haircut, and 7+ since he last put on a tie. His pandemic wardrobe, he said, is "just a question of which sweatsuit I wear."

18.01.2022 How can more people live an interesting life? It’s very, very simple... Guy Raz tells us how to live an interesting life Noah Kagan -- a longtime friend of The Hustle -- is the mind behind OkDork, a YouTube channel which draws amazing lessons from 8-figure founders. To date, it has 85k subs and you can subscribe here.... Kagan recently did a Q&A with Guy Raz, host of the popular business podcast How I Built This. Kagan took time to ask Raz a few questions specifically for The Hustle’s readers: What is an interesting life? Doing things that are interesting to me and keep my brain firing. Journalism, reporting, interviewing people, and telling stories did that for me. All that, over time, evolved into what I do now. How can more people live an interesting life? It’s very, very simple. In our culture, we elevate intelligence and think it’s so important. The reality is intelligence is incredibly overrated. Having an interesting life is just choosing to be curious. This means exposing yourself to ideas, to books, to themes, to shows, to people. I first interviewed a cosmetics founder a few years ago and was not interested at all in cosmetics. So all I did was choose to be curious and now I am endlessly fascinated with cosmetics. What is the perfect Guy Raz dinner party question? One question is not enough. You can ask: What’s your greatest fear? Your biggest desire? Your biggest failure? But those questions don’t always elicit great answers. The reality is that every single person has a story to tell. They’ve gone through a crisis, had heartache, suffered loss, etc. What I’ve found is when you really know someone’s story, it’s really hard to not empathize with them. In a perfect world, we would all know each other’s stories. So at a perfect dinner party, I would want everyone to tell their life story.

18.01.2022 A Covid pandemic places Cancer patients under the survival pump

17.01.2022 Meet the new jobs of the reopening economy On the beach, a volunteer might make sure your sandcastle doesn’t get too close to your neighbor’s. At your favorite restaurant, a bathroom attendant may watch over the lines for the urinals and stalls, so they don’t get too crowded.... At home, a stranger might call to see if you’ve been exposed. The coronavirus crisis shuttered businesses nationwide and sent the US unemployment rate soaring to levels not seen since the Great Depression. As the economy reopens, America’s workforce will change -- and we’ll see new jobs emerge. Make way for the contact-tracing army NPR has been surveying states on their plans for contact tracing. It found that they’ve hired 11k+ tracers so far, with plans to expand those ranks to 66k+. A labor market economist told Bloomberg that contact tracing could create as many as 250k jobs in the US. The New York Times reported that the market for contact tracers is surprisingly competitive -- and doing the job well requires finesse, to develop trust with a stranger after calling them out of the blue. One caveat: The FTC is warning people not to be too trusting. On Tuesday, it said contact-tracing text scams were on the rise. Check out the temperature checkers Among the other occupations coming soon to a help-wanted section near you: Companies of all sizes are hiring workers to check the temperatures of staff and visitors. Retailers are already shifting workers to tasks like monitoring doors and making sure customers comply with social-distancing rules. Cart sanitizer is a distinct role some retailers are hiring for -- the job is part of a coming cleaning boom. Silicon Valley jobs are getting weird Protocol perused the job listings at some of America’s biggest tech companies, and found that things are getting dark: Google, for one, is hiring a policy enforcement manager to prevent content violating YouTube’s policies from showing up on the site -- with a focus on suicide and self-harm. Tesla is hiring a community relations partner in Fremont, California, the home of its recently embattled factory. To the person who wants that gig, we say: Good luck with that.

17.01.2022 Very interesting opportunity unfolding- It all started with a honeymoon... In 2012, our co-founder Mark and his wife Rachel bought an RV to travel the country for their honeymoon. Not only did the RV allow them to see the country in a whole new way, it gave them the freedom to go at their own pace.... Once the newlyweds returned home, they realized their RV would sit unused for the majority of the year, yet they still had all of the expenses of RV ownership. Mark discovered that renting out his RV was an opportunity to not only offset the costs of his RV, but also a way to share all the perks of RVing with people who weren’t sure if they wanted to own one. After trying to rent it out, Mark learned that there was no ideal platform to support the idea. After doing more research he discovered the untapped market of peer-to-peer RV rentals. Fast forward to today. RVshare is the world’s first and largest peer-to-peer RV rental marketplace, serving more than 60,000 RV owners across the US. With thousands of satisfied customers and a broad inventory ranging from travel trailers to luxury motorhomes, we have the perfect RV for your vacation, tailgate, or temporary lodging needs. RV Renters. Meet RV Owners. Families everywhere want to rent an RV and taste the open road for themselves. Meanwhile, the average family’s RV will sit unused for approximately 90% of the year. We’re here to bring RV renters and RV owners together. If you want the comforts of home while getting up close and personal with the beautiful world around you, an RV rental is the best place to start. Renters can use the filters to find the RV that perfectly fits what they are looking for. Whether that be a pet-friendly Class C for the family, or a Pop-Up Camper for a romantic getaway, we’ve got you covered. https://rvshare.com

17.01.2022 A move in the right direction- it captures one of my bio markers - high TMB - this, I think was what separated me from the other 8 participants that were unsuccessful on Keynote trial 158. Keytruda (Pembro...) by Merck continues to open up new possibilities -

14.01.2022 Key statistics 68,986 doctor certified deaths occurred between 1 January 2020 and 30 June 2020. Numbers of deaths have been below historical averages since mid May and below baseline minimums since the week ending 9 June.... Deaths from respiratory diseases and heart diseases were below historical minimum counts throughout June.

12.01.2022 Claire's "tech by girls" network has developed a new "Professional Profiles" range - "PT Villager Series" - Made as a personalised Mobile business card. I have attached the female Version https://techbygirls.com.au/pt-villager-female/ If you know any personal trainers wanting to create their own brand then these could be just the ticket - let me know and I will connect you to Claire - not too shabby for $500... Steve www.steveholmes.net.au

09.01.2022 Thoughts! Vaccine Wars & People/m2 - the new currency This will become the most divisive topic of 2021/2. ...Continue reading

09.01.2022 What’s happening in the USA- Consumer spending is up, but don’t call it a comeback Accounting for of US economic output, consumer spending is a big effing deal. The good news? Spending is up! ... The bad news? Our collective wallet’s gonna snap shut again as COVID cases rise in many states. The data on our spending habits paints an interesting picture: Many of us seem ready to hunker down for the long haul. Social distancing is getting old, but without an end in sight, we’re looking for ways to improve our domestic lives. Home is where the heart is We’re staying put, and we’re splurging on around-the-house projects: Home-improvement spending is up 40%. Furniture sales are up 28%. Many of us have grown more ambitious in the kitchen, but food-delivery spending via services like Grubhub and UberEats is up ~186% compared to pre-pandemic weekly averages. At-home drinking is also up. One survey found that 44% won’t be back in the bars for a long time. Sales at wine and liquor stores, meanwhile, continue to show double-digit increases. Demand for aluminum cans is now so high that some beverages -- like the underrated Fresca -- have been pushed off the shelves. But cabin fever is real, man Spending on Airbnb and HomeAway bookings are up 6% compared with the same period last year, but people are still avoiding crowded spaces like airports and hotels. Even if travel isn’t in the cards for everyone, we want to get out. Sales of sporting equipment shot up 48% compared to last year, for the week ending June 24. Good luck getting your butt on a bike.

08.01.2022 Geographic Patterns of Early-Onset Colorectal Cancer Diagnoses in the United States "The team then studied a variety of factors of the diagnoses in these hotspot counties; these included age, race, tumor stage and grade, treatment approach, and marital status. In the hotspot counties, they identified that death rates in non-Hispanic black and Hispanic men with early-onset colorectal cancer outpaced other racial groups studied...." https://www.ascopost.com//geographic-patterns-of-early-ons

06.01.2022 STORAGE WARS Wanna make that spare closet earn its keep? This startup can help You’ve got a spare bedroom, but having strangers sleep over feels weird. No worries -- you can still monetize that square footage. Neighbor aims to be the Airbnb of self-storage, connecting people who have STUFF with people who have SPACE. ... Homeowners might be its bread and butter, but there’s value in thinking outside the box: Neighbor just inked a deal with a major developer to transform office ghost towns into storage spaces. The storage biz is all about the 4 D’s Death, downsize, divorce and disaster keep demand flowing in bad times, as one storage exec told The New York Times. And what’s a bigger disaster than a pandemic? Students were kicked off campuses, and others gave up apartments to shelter in place with family. Dumbo Moving + Storage, which has 5 facilities in New York and New Jersey, had 2.6k+ new customers in May, up 35% from last year. So there’s plenty of space for Neighbor Its rates tend to be ~50% lower than traditional storage facilities, which charge up to $225/month for a climate-controlled unit. Neighbor estimates a whole basement can pull in ~$3.1k/year. An empty closet? $384/year.

06.01.2022 Nextdoor is looking at a $4B+ IPO. Is it ready? In an incredible technological achievement, Nextdoor has made being a nosy neighbor socially acceptable. Founded in 2008, the SF-based private firm dubs itself as a neighborhood hub, where trusted connections can exchange goods, services, and info.... Today, 1 in 4 US neighborhoods reportedly use the platform. Nextdoor wants to ride the ‘going public’ wave According to Bloomberg, the firm is eyeing a valuation between $4B and $5B in a public listing. Last year, it raised $170m at a $2.1B valuation. Actual revenue figures are unclear, but the firm makes money in 3 ways: Sponsored Ads: Local and regional businesses advertise in the newsfeed Neighborhood Sponsorship: Local home service experts and real estate brokers can promote themselves in certain zip codes Local Deals: Neighborhood businesses can advertise special offers to members in their area Run by Square’s former CFO (Sarah Friar), Nextdoor is aiming to create a hyper-localized advertising empire (e.g., Yelp, but it's your neighbors). The pandemic has brought out the good and bad Back in March, Nextdoor’s number of daily active users surged 80% month-over-month -- largely thanks to the platform’s efforts to provide localized safety updates, help elderly neighbors, and support local businesses. Months later, in the wake of George Floyd’s death, the company was mired in controversy around Black Lives Matter-related posts. For years, Nextdoor has faced accusations of racial profiling on its platform. In response, it has changed its moderation policy and enlisted more Black moderators. New Nextdoor products are trying to right the ship Among them: A Kindness Reminder to stop abusive posts before they start Help Maps that give an interactive map for people to offer real-time help They should move fast: Facebook just started trialing a similar service called Neighborhood. Even more worrying than Facebook, some users don’t take the platform seriously. An extremely popular Twitter account (Best of Nextdoor) combs the platform far and wide, curating ridiculous posts. Maybe it is technologically impossible to make nosy neighbors cool.

05.01.2022 The trend has come to us. The future of connectedness is to embrace localism and create Villages full of Villagers COVID 19 has enhanced this. Destination Main Beach is fast becoming a great example of this - a grassroots Postmodern Villager Revival. Villagers reclaiming their village, their shared values, visions and aspirations - a very powerful adjustment to globalisation.... Take a look at https://destinationmainbeach.com.au

05.01.2022 Sensible Economics https://youtu.be/5MHJL-jc-Io

04.01.2022 An excerpt of reality from the Australian Reserve Bank today - The choices appear to be straight ahead and crash - or make a sharp left turn to a new normal? But happened to the right turn option? Dr Lowe said deflationary pressures, increased savings and large shortfalls in potential economic activity all meant interest rates would stay low for an extended period of time. "I think it's likely we're going to see interest rates at their current level for years," he said.... "We do face a world where there'll be a shadow from the virus for quite a few years. People will be more risk-averse, they won't want to borrow, in Australia we're going to have lower population dynamics." Dr Lowe said it made sense for governments and central banks to "throw everything" at supporting the economy during the depths of the pandemic. https://apple.news/AbBePldShTeCX_8vlnfMG2w

02.01.2022 Can Opendoor’s iBuying bring the trillion-dollar housing market online? Here is Opendoor’s pitch from its website: Sell your home from the comfort of your couch. Like, from your iPhone.... Billionaire investor Chamath Palihapitiya likes the pitch so much that he recently announced he’ll be taking Opendoor public via a SPAC ($IPOB). The deal values the real estate startup at $4.8B and Palihapitiya believes it will be a 10x in 10 years play. Consumer real estate is a $1.6T opportunity As explained in a one-page investment thesis Palihapitiya posted on Twitter. The document further explains the pain of the current buying process: it’s offline, slow, inconvenient, unpopular (low NPS) and -- with less than 1% of its sales done digitally -- ripe for disruption. Opendoor was launched 6 years ago to tackle this problem with an iBuying solution and -- to date -- has done $10B in home sales and worked with 80k homeowners, per the company’s investor presentation. How it works Opendoor allows you to digitally buy or sell a home through these steps: Pricing: A real-time pricing model that tells you how much a home is worth click buy. Home ops: If there’s a sale, the company handles inspection, data collection, repairs, and renovations. Fulfillment: The closing process is automated. Its pricing model has been trained on 145 unique features (e.g., countertops, roofs), and the company has conducted 175k on-site inspections. Currently, its margin on a home sale is 4%, but Opendoor believes it could reach 7% with better pricing and upsells (e.g., titles and escrow services). Opendoor currently operates in 21 US markets With annual revenues of ~$5B. The company says its playbook can be successfully implemented across the US, ringing up $50B per year. At a macro level, Palihapitiya notes the following tailwinds: Americans relocating because of housing affordability issues 75m millennials will soon enter the homebuying market Working from home is here to stay, meaning you can be location agnostic If imitation is the sincerest form of flattery, then $22B real estate marketplace Zillow has flattered the sh*t out of Opendoor (and validated its business model) by making iBuying a mission-critical part of its business.

01.01.2022 dMMR / MSi-High and PD-L1 Could more patients qualify and be successful from the Immune Checkpoint Pathway? I know these journal styled reports can be difficult to follow, but this report is worth the effort. ... It further dissects the (ICI) checkpoint pathway and opens up the possibility of a wider patient catchment for this treatment- Note: Keynote trial 158; I am one of the 233 global cohort - and one of just 9 in the sub cohort of Cholangiocarcinoma Patients. Within this sub cohort I am the only full and complete response - ie NED / Remission on this phase2 trial. They observed and highlight, that patient with mutations displaying a high tumor burden (TMB) was potentially a defining factor in their successful outcomes. They also observed that MSS - Microsatellite Stable mutations could still have a high TMB and potentially inline for successful treatment outcomes. I agree with this observation and their reasoning - see higher concentration of neoantigens and visibility Addition reading https://ascopost.com//does-pembrolizumab-show-activity-in- Steve My CCA Patient interview- https://cholangiocarcinoma.com.au/steve-holmes-patient/